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Annual Review of Virology

Volume 9, 2022

Systems Biology of Virus-Host Protein Interactions: From Hypothesis Generation to Mechanisms of Replication and Pathogenesis

Abstract

As obligate intracellular parasites, all viruses must co-opt cellular machinery to facilitate their own replication. Viruses often co-opt these cellular pathways and processes through physical interactions between viral and host proteins. In addition to facilitating fundamental aspects of virus replication cycles, these virus-host protein interactions can also disrupt physiological functions of host proteins, causing disease that can be advantageous to the virus or simply a coincidence. Consequently, unraveling virus-host protein interactions can serve as a window into molecular mechanisms of virus replication and pathogenesis. Identifying virus-host protein interactions using unbiased systems biology approaches provides an avenue for hypothesis generation. This review highlights common systems biology approaches for identification of virus-host protein interactions and the mechanistic insights revealed by these methods. We also review conceptual innovations using comparative and integrative systems biology that can leverage global virus-host protein interaction data sets to more rapidly move from hypothesis generation to mechanism.

Keyword(s): protein interactions, proteomics, systems biology
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/content/journals/10.1146/annurev-virology-100520-011851
2022-09-29
2024-05-23
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/content/journals/10.1146/annurev-virology-100520-011851
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Systems Biology of Virus-Host Protein Interactions: From Hypothesis Generation to Mechanisms of Replication and Pathogenesis
Annual Review of Virology 9, 397 (2022); https://doi.org/10.1146/annurev-virology-100520-011851
/content/journals/10.1146/annurev-virology-100520-011851
/content/journals/10.1146/annurev-virology-100520-011851
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