1932

Abstract

The FF ATP synthase is a large multisubunit complex that couples translocation of protons down an electrochemical gradient to the synthesis of ATP. Recent advances in structural analyses have led to the demonstration that the enzyme utilizes a rotational catalytic mechanism. Kinetic and biochemical evidence is consistent with the expected equal participation of the three catalytic sites in the αβ hexamer, which operate in sequential, cooperative reaction pathways. The rotation of the core γ subunit plays critical roles in establishing the conformation of the sites and the cooperative interactions. Mutational analyses have shown that the rotor subunits are responsible for coupling and in doing so transmit specific conformational information between transport and catalysis.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.biophys.28.1.205
1999-06-01
2024-06-22
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.biophys.28.1.205
Loading
/content/journals/10.1146/annurev.biophys.28.1.205
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error