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Annual Review of Pathology: Mechanisms of Disease

Volume 18, 2023

Pathogenesis of Zika Virus Infection

Abstract

Zika virus (ZIKV) is an emerging virus from the family that is transmitted to humans by mosquito vectors and represents an important health problem. Infections in pregnant women are of major concern because of potential devastating consequences during pregnancy and have been associated with microcephaly in newborns. ZIKV has a unique ability to use the host machinery to promote viral replication in a tissue-specific manner, resulting in characteristic pathological disorders. Recent studies have proposed that the host ubiquitin system acts as a major determinant of ZIKV tropism by providing the virus with an enhanced ability to enter new cells. In addition, ZIKV has developed mechanisms to evade the host immune response, thereby allowing the establishment of viral persistence and enhancing viral pathogenesis. We discuss recent reports on the mechanisms used by ZIKV to replicate efficiently, and we highlight potential new areas of research for the development of therapeutic approaches.

Keyword(s): antagonism of immune responses, pathogenesis, TRIM7, tropism, ubiquitin, Zika virus
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/content/journals/10.1146/annurev-pathmechdis-031521-034739
2023-01-24
2024-05-01
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/content/journals/10.1146/annurev-pathmechdis-031521-034739
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Pathogenesis of Zika Virus Infection
Annual Review of Pathology: Mechanisms of Disease 18, 181 (2023); https://doi.org/10.1146/annurev-pathmechdis-031521-034739
/content/journals/10.1146/annurev-pathmechdis-031521-034739
/content/journals/10.1146/annurev-pathmechdis-031521-034739
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