1932

Abstract

Several peer-reviewed papers and reviews have examined the relationship between exposure to air pollution and COVID-19 spread and severity. However, many of the existing reviews on this topic do not extensively present the statistical challenges associated with this field, do not provide comprehensive guidelines for future researchers, and review only the results of a relatively small number of papers. We reviewed 139 papers, 127 of which reported a statistically significant positive association between air pollution and adverse COVID-19 health outcomes. Here, we summarize the evidence, describe the statistical challenges, and make recommendations for future research. To summarize the 139 papers with data from geographical locations around the world, we also present anopen-source data visualization tool that summarizes these studies and allows the research community to contribute evidence as new research papers are published.

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/content/journals/10.1146/annurev-publhealth-071521-120424
2023-04-03
2024-04-26
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Literature Cited

  1. 1.
    Ali N, Islam F. 2020. The effects of air pollution on COVID-19 infection and mortality—a review on recent evidence. Front. Public Health 8:580057
    [Google Scholar]
  2. 2.
    Ayoub Meo S, Adnan Abukhalaf A, Sami W, Hoang TD 2021. Effect of environmental pollution PM2.5, carbon monoxide, and ozone on the incidence and mortality due to SARS-CoV-2 infection in London, United Kingdom. J. King Saud Univ. Sci. 33:101373
    [Google Scholar]
  3. 3.
    Azuma K, Kagi N, Kim H, Hayashi M. 2020. Impact of climate and ambient air pollution on the epidemic growth during COVID-19 outbreak in Japan. Environ. Res. 190:110042
    [Google Scholar]
  4. 4.
    Ben Maatoug A, Triki MB, Fazel H. 2021. How do air pollution and meteorological parameters contribute to the spread of COVID-19 in Saudi Arabia?. Environ. Sci. Pollut. Res. Int. 28:44132–39
    [Google Scholar]
  5. 5.
    Benmarhnia T. 2020. Linkages between air pollution and the health burden from COVID-19: methodological challenges and opportunities. Am. J. Epidemiol. 189:1238–43
    [Google Scholar]
  6. 6.
    Bigdeli M, Taheri M, Mohammadian A. 2021. Spatial sensitivity analysis of COVID-19 infections concerning the satellite-based four air pollutants levels. Int. J. Environ. Sci. Technol. 18:751–60
    [Google Scholar]
  7. 7.
    Bourdrel T, Annesi-Maesano I, Alahmad B, Maesano CN, Bind M-A. 2021. The impact of outdoor air pollution on COVID-19: a review of evidence from in vitro, animal, and human studies. Eur. Respir. Rev. 30:200242
    [Google Scholar]
  8. 8.
    Bowe B, Xie Y, Gibson AK, Cai M, van Donkelaar A et al. 2021. Ambient fine particulate matter air pollution and the risk of hospitalization among COVID-19 positive individuals: cohort study. Environ. Int. 154:106564
    [Google Scholar]
  9. 9.
    Cartenì A, Cascetta F, Di Francesco L, Palermo F. 2021. Particulate matter short-term exposition, mobility trips and COVID-19 diffusion: a correlation analyses for the Italian Case Study at Urban Scale. Sustainability 13:4553
    [Google Scholar]
  10. 10.
    Chadeau-Hyam M, Bodinier B, Elliott J, Whitaker MD, Tzoulaki I et al. 2020. Risk factors for positive and negative COVID-19 tests: a cautious and in-depth analysis of UK biobank data. Int. J. Epidemiol. 49:1454–67
    [Google Scholar]
  11. 11.
    Chakrabarty RK, Beeler P, Liu P, Goswami S, Harvey RD et al. 2021. Ambient PM2.5 exposure and rapid spread of COVID-19 in the United States. Sci. Total Environ. 760:143391
    [Google Scholar]
  12. 12.
    Chowkwanyun M, Reed AL Jr. 2020. Racial health disparities and COVID-19—caution and context. N. Engl. J. Med. 383:201–3
    [Google Scholar]
  13. 13.
    Clougherty JE. 2010. A growing role for gender analysis in air pollution epidemiology. Environ. Health Perspect. 118:167–76
    [Google Scholar]
  14. 14.
    Coker ES, Cavalli L, Fabrizi E, Guastella G, Lippo E et al. 2020. The effects of air pollution on COVID-19 related mortality in northern Italy. Environ. Resour. Econ. 76:611–34
    [Google Scholar]
  15. 15.
    Copat C, Cristaldi A, Fiore M, Grasso A, Zuccarello P et al. 2020. The role of air pollution (PM and NO2) in COVID-19 spread and lethality: a systematic review. Environ. Res. 191:110129
    [Google Scholar]
  16. 16.
    Dales R, Blanco-Vidal C, Romero-Meza R, Schoen S, Lukina A, Cakmak S. 2021. The association between air pollution and COVID-19 related mortality in Santiago, Chile: a daily time series analysis. Environ. Res. 198:111284
    [Google Scholar]
  17. 17.
    Davies B, Parkes BL, Bennett J, Fecht D, Blangiardo M et al. 2021. Community factors and excess mortality in first wave of the COVID-19 pandemic in England. Nat. Commun. 12:3755
    [Google Scholar]
  18. 18.
    De Angelis E, Renzetti S, Volta M, Donato F, Calza S et al. 2021. COVID-19 incidence and mortality in Lombardy, Italy: an ecological study on the role of air pollution, meteorological factors, demographic and socioeconomic variables. Environ. Res. 195:110777
    [Google Scholar]
  19. 19.
    Dominici F, Zeger SL, Samet JM. 2000. A measurement error model for time-series studies of air pollution and mortality. Biostatistics 1:157–75
    [Google Scholar]
  20. 20.
    Fernández D, Giné-Vázquez I, Liu I, Yucel R, Nai Ruscone M et al. 2021. Are environmental pollution and biodiversity levels associated to the spread and mortality of COVID-19? A four-month global analysis. Environ. Pollut. 271:116326
    [Google Scholar]
  21. 21.
    Ficetola GF, Rubolini D. 2021. Containment measures limit environmental effects on COVID-19 early outbreak dynamics. Sci. Total Environ. 761:144432
    [Google Scholar]
  22. 22.
    Filippini T, Rothman KJ, Cocchio S, Narne E, Mantoan D et al. 2021. Associations between mortality from COVID-19 in two Italian regions and outdoor air pollution as assessed through tropospheric nitrogen dioxide. Sci. Total Environ. 760:143355
    [Google Scholar]
  23. 23.
    Frontera A, Cianfanelli L, Vlachos K, Landoni G, Cremona G. 2020. Severe air pollution links to higher mortality in COVID-19 patients: the “double-hit” hypothesis. J. Infect. 81:255–59
    [Google Scholar]
  24. 24.
    Gandhi TK, Singh H. 2020. Reducing the risk of diagnostic error in the COVID-19 era. J. Hosp. Med. 15:363–66
    [Google Scholar]
  25. 25.
    Gryparis A, Paciorek CJ, Zeka A, Schwartz J, Coull BA. 2009. Measurement error caused by spatial misalignment in environmental epidemiology. Biostatistics 10:258–74
    [Google Scholar]
  26. 26.
    Han Y, Lam JCK, Li VOK, Crowcroft J, Fu J et al. 2021. Outdoor PM2.5 concentration and rate of change in COVID-19 infection in provincial capital cities in China. Sci. Rep. 11:23206
    [Google Scholar]
  27. 27.
    Haneuse S, VanderWeele TJ, Arterburn D. 2019. Using the E-value to assess the potential effect of unmeasured confounding in observational studies. JAMA 321:602–3
    [Google Scholar]
  28. 28.
    Hendryx M, Luo J. 2020. COVID-19 prevalence and fatality rates in association with air pollution emission concentrations and emission sources. Environ. Pollut. 265:115126
    [Google Scholar]
  29. 29.
    Huang H, Liang X, Huang J, Yuan Z, Ouyang H et al. 2020. Correlations between meteorological indicators, air quality and the COVID-19 pandemic in 12 cities across China. J. Environ. Health Sci. Eng. 18:1491–98
    [Google Scholar]
  30. 30.
    Isphording IE, Pestel N. 2021. Pandemic meets pollution: Poor air quality increases deaths by COVID-19. J. Environ. Econ. Manag. 108:102448
    [Google Scholar]
  31. 31.
    Jackson C, Best N, Richardson S. 2008. Hierarchical related regression for combining aggregate and individual data in studies of socio-economic disease risk factors. J. R. Stat. Soc. A Stat. Soc. 171:159–78
    [Google Scholar]
  32. 32.
    Jain M, Sharma GD, Goyal M, Kaushal R, Sethi M. 2021. Econometric analysis of COVID-19 cases, deaths, and meteorological factors in South Asia. Environ. Sci. Pollut. Res. Int. 28:28518–34
    [Google Scholar]
  33. 33.
    Jiang Y, Xu J. 2021. The association between COVID-19 deaths and short-term ambient air pollution/meteorological condition exposure: a retrospective study from Wuhan, China. Air Qual. Atmos. Health 14:1–5
    [Google Scholar]
  34. 34.
    Konstantinoudis G, Padellini T, Bennett J, Davies B, Ezzati M, Blangiardo M. 2021. Long-term exposure to air-pollution and COVID-19 mortality in England: a hierarchical spatial analysis. Environ. Int. 146:106316
    [Google Scholar]
  35. 35.
    Künzli N, Tager IB. 1997. The semi-individual study in air pollution epidemiology: a valid design as compared to ecologic studies. Environ. Health Perspect. 105:1078–83
    [Google Scholar]
  36. 36.
    Liang D, Shi L, Zhao J, Liu P, Sarnat JA et al. 2020. Urban air pollution may enhance COVID-19 case-fatality and mortality rates in the United States. Innovation 1:3100047
    [Google Scholar]
  37. 37.
    Lipsitt J, Chan-Golston AM, Liu J, Su J, Zhu Y, Jerrett M. 2021. Spatial analysis of COVID-19 and traffic-related air pollution in Los Angeles. Environ. Int. 153:106531
    [Google Scholar]
  38. 38.
    López-Feldman A, Heres D, Marquez-Padilla F. 2021. Air pollution exposure and COVID-19: a look at mortality in Mexico City using individual-level data. Sci. Total Environ. 756:143929
    [Google Scholar]
  39. 39.
    Marquès M, Domingo JL. 2022. Positive association between outdoor air pollution and the incidence and severity of COVID-19. A review of the recent scientific evidences. Environ. Res. 203:111930
    [Google Scholar]
  40. 40.
    Martelletti L, Martelletti P. 2020. Air pollution and the novel COVID-19 disease: a putative disease risk factor. SN Compr. . Clin. Med. 2:383–87
    [Google Scholar]
  41. 41.
    Mathur MB, Ding P, Riddell CA, VanderWeele TJ. 2018. Web site and R package for computing E-values. Epidemiology 29:e45–47
    [Google Scholar]
  42. 42.
    McLaughlin JM, Khan F, Pugh S, Angulo FJ, Schmitt H-J et al. 2021. County-level predictors of coronavirus disease 2019 (COVID-19) cases and deaths in the United States: What happened, and where do we go from here?. Clin. Infect. Dis. 73:e1814–21
    [Google Scholar]
  43. 43.
    Middya AI, Roy S 2021. Geographically varying relationships of COVID-19 mortality with different factors in India. Sci. Rep. 11:7890
    [Google Scholar]
  44. 44.
    Mutambudzi M, Niedwiedz C, Macdonald EB, Leyland A, Mair F et al. 2020. Occupation and risk of severe COVID-19: prospective cohort study of 120 075 UK Biobank participants. Occup. Environ. Med. 78:307–14
    [Google Scholar]
  45. 45.
    Nelson A. 2022. Let's clear the air on COVID. Off. Sci. Technol. Policy Blog March 23. https://www.whitehouse.gov/ostp/news-updates/2022/03/23/lets-clear-the-air-on-covid/
    [Google Scholar]
  46. 46.
    Pei L, Wang X, Guo B, Guo H, Yu Y. 2021. Do air pollutants as well as meteorological factors impact corona virus disease 2019 (COVID-19)? Evidence from China based on the geographical perspective. Environ. Sci. Pollut. Res. 28:35584–96
    [Google Scholar]
  47. 47.
    Petroni M, Hill D, Younes L, Barkman L, Howard S et al. 2020. Hazardous air pollutant exposure as a contributing factor to COVID-19 mortality in the United States. Environ. Res. Lett. 15:0940a9
    [Google Scholar]
  48. [Google Scholar]
  49. 49.
    Rodriguez-Diaz CE, Guilamo-Ramos V, Mena L, Hall E, Honermann B et al. 2020. Risk for COVID-19 infection and death among Latinos in the United States: examining heterogeneity in transmission dynamics. Ann. Epidemiol. 52:46–53.e2
    [Google Scholar]
  50. 50.
    Rozenfeld Y, Beam J, Maier H, Haggerson W, Boudreau K et al. 2020. A model of disparities: risk factors associated with COVID-19 infection. Int. J. Equity Health 19:126
    [Google Scholar]
  51. 51.
    Saez M, Tobias A, Barceló MA. 2020. Effects of long-term exposure to air pollutants on the spatial spread of COVID-19 in Catalonia, Spain. Environ. Res. 191:110177
    [Google Scholar]
  52. 52.
    Schwartz J. 2000. The distributed lag between air pollution and daily deaths. Epidemiology 11:320–26
    [Google Scholar]
  53. 53.
    Setti L, Passarini F, De Gennaro G, Barbieri P, Licen S et al. 2020. Potential role of particulate matter in the spreading of COVID-19 in Northern Italy: first observational study based on initial epidemic diffusion. BMJ Open 10:e039338
    [Google Scholar]
  54. 54.
    Sittig DF, Singh H. 2020. COVID-19 and the need for a national health information technology infrastructure. JAMA 323:2373–74
    [Google Scholar]
  55. 55.
    Stieb DM, Evans GJ, To TM, Brook JR, Burnett RT. 2020. An ecological analysis of long-term exposure to PM2.5 and incidence of COVID-19 in Canadian health regions. Environ. Res. 191:110052
    [Google Scholar]
  56. 56.
    Szpiro AA, Sheppard L, Lumley T. 2011. Efficient measurement error correction with spatially misaligned data. Biostatistics 12:610–23
    [Google Scholar]
  57. 57.
    Travaglio M, Yu Y, Popovic R, Selley L, Leal NS, Martins LM. 2021. Links between air pollution and COVID-19 in England. Environ. Pollut. 268:115859
    [Google Scholar]
  58. 58.
    Villeneuve PJ, Goldberg MS. 2020. Methodological considerations for epidemiological studies of air pollution and the SARS and COVID-19 coronavirus outbreaks. Environ. Health Perspect. 128:95001
    [Google Scholar]
  59. 59.
    Wakefield J, Salway R. 2001. A statistical framework for ecological and aggregate studies. J. R. Stat. Soc. A Stat. Soc. 164:119–37
    [Google Scholar]
  60. 60.
    Wang B, Liu J, Li Y, Fu S, Xu X et al. 2020. Airborne particulate matter, population mobility and COVID-19: a multi-city study in China. BMC Public Health 20:1585
    [Google Scholar]
  61. 61.
    Wu X, Nethery RC, Sabath MB, Braun D, Dominici F. 2020. Air pollution and COVID-19 mortality in the United States: strengths and limitations of an ecological regression analysis. Sci. Adv. 6:eabd4049
    [Google Scholar]
  62. 62.
    Xu H, Yan C, Fu Q, Xiao K, Yu Y et al. 2020. Possible environmental effects on the spread of COVID-19 in China. Sci. Total Environ. 731:139211
    [Google Scholar]
  63. 63.
    Yancy CW. 2020. COVID-19 and African Americans. JAMA 323:1891–92
    [Google Scholar]
  64. 64.
    Yao Y, Pan J, Liu Z, Meng X, Wang W et al. 2021. Ambient nitrogen dioxide pollution and spreadability of COVID-19 in Chinese cities. Ecotoxicol. Environ. Safety 208:111421
    [Google Scholar]
  65. 65.
    Yates EF, Zhang K, Naus A, Forbes C, Wu X, Dey T. 2022. A review on the biological, epidemiological, and statistical relevance of COVID-19 paired with air pollution. Environ. Adv. 8:100250
    [Google Scholar]
  66. 66.
    Yu X, Wong MS, Kwan MP, Nichol JE, Zhu R et al. 2021. COVID-19 infection and mortality: association with PM2.5 concentration and population density—an exploratory study. ISPRS Int. J. Geo-Inf. 10:123
    [Google Scholar]
  67. 67.
    Zhang Z, Xue T, Jin X 2020. Effects of meteorological conditions and air pollution on COVID-19 transmission: evidence from 219 Chinese cities. Sci. Total Environ. 741:140244
    [Google Scholar]
  68. 68.
    Zhao C, Fang X, Feng Y, Fang X, He J, Pan H. 2021. Emerging role of air pollution and meteorological parameters in COVID-19. J. Evid. Based Med. 14:123–38
    [Google Scholar]
  69. 69.
    Zhu Y, Xie J, Huang F, Cao L. 2020. Association between short-term exposure to air pollution and COVID-19 infection: evidence from China. Sci. Total Environ. 727:138704
    [Google Scholar]
  70. 70.
    Zhu Y, Xie J, Huang F, Cao L. 2020. The mediating effect of air quality on the association between human mobility and COVID-19 infection in China. Environ. Res. 189:109911
    [Google Scholar]
  71. 71.
    Zoran MA, Savastru RS, Savastru DM, Tautan MN. 2020. Assessing the relationship between ground levels of ozone (O3) and nitrogen dioxide (NO2) with coronavirus (COVID-19) in Milan, Italy. Sci. Total Environ. 740:140005
    [Google Scholar]
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