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Annual Review of Cancer Biology

Volume 8, 2024

The Intestinal Microbiota and Therapeutic Responses to Immunotherapy

Abstract

The intestinal microbiota, a complex ecosystem of microorganisms, has emerged as an important player in modulating various aspects of human health and disease. The microbiota is in a state of constant cross talk with itself and its host, and these interactions regulate several aspects of host homeostasis, including immune responses. Studies have demonstrated a relationship between the microbiota and outcomes of several cancer immunotherapies. This review explores the different roles of intestinal microbiota in shaping the efficacy and safety of cancer immunotherapies, including allogeneic hematopoietic cell transplantation, immune checkpoint blockade, and CAR T cell therapy.

Keyword(s): allo-HCT, allogeneic hematopoietic cell transplantation, CAR T cell therapy, dysbiosis, immune checkpoint inhibitors, immunotherapy, microbiota
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/content/journals/10.1146/annurev-cancerbio-062722-035210
2024-06-12
2025-04-18
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/content/journals/10.1146/annurev-cancerbio-062722-035210
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The Intestinal Microbiota and Therapeutic Responses to Immunotherapy
Annual Review of Cancer Biology 8, 435 (2024); https://doi.org/10.1146/annurev-cancerbio-062722-035210
/content/journals/10.1146/annurev-cancerbio-062722-035210
/content/journals/10.1146/annurev-cancerbio-062722-035210
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  • Article Type: Review Article

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