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Annual Review of Pathology: Mechanisms of Disease

Volume 18, 2023

Orchestration of Collective Migration and Metastasis by Tumor Cell Clusters

Abstract

Metastatic dissemination has lethal consequences for cancer patients. Accruing evidence supports the hypothesis that tumor cells can migrate and metastasize as clusters of cells while maintaining contacts with one another. Collective metastasis enables tumor cells to colonize secondary sites more efficiently, resist cell death, and evade the immune system. On the other hand, tumor cell clusters face unique challenges for dissemination particularly during systemic dissemination. Here, we review recent progress toward understanding how tumor cell clusters overcome these disadvantages as well as mechanisms they utilize to gain advantages throughout the metastatic process. We consider useful models for studying collective metastasis and reflect on how the study of collective metastasis suggests new opportunities for eradicating and preventing metastatic disease.

Keyword(s): circulating tumor cell clusters, collective metastasis, collective migration, collective signaling, polyclonal seeding
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/content/journals/10.1146/annurev-pathmechdis-031521-023557
2023-01-24
2024-05-14
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/content/journals/10.1146/annurev-pathmechdis-031521-023557
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Orchestration of Collective Migration and Metastasis by Tumor Cell Clusters
Annual Review of Pathology: Mechanisms of Disease 18, 231 (2023); https://doi.org/10.1146/annurev-pathmechdis-031521-023557
/content/journals/10.1146/annurev-pathmechdis-031521-023557
/content/journals/10.1146/annurev-pathmechdis-031521-023557
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