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Annual Review of Animal Biosciences

Volume 6, 2018

Metabolic and Endocrine Role of Adipose Tissue During Lactation

Abstract

The adipose tissue serves an essential role for survival and reproduction in mammals, especially females. It serves primarily as an energy storage organ and is directly linked to the reproductive success of mammals. In wild animals, adipose tissue function is linked to seasonality of the food supply to support fetal growth and milk production. Adipose tissue depots in ruminants and non-ruminants can secrete many signal molecules (adipokines) that act as hormones and as pro- and anti-inflammatory cytokines. The visceral adipose tissue especially appears to be more endocrinologically active than other adipose depots. The endocrine function is important for the overall long-term regulation of energy metabolism and plays an important role in the adaptation to lactation in many mammalian species, including humans. Furthermore, endocrine signals from adipose tissue depots contribute to fertility modulation, immune function, and inflammatory response. Energy homeostasis is modulated by changes in feed intake, insulin sensitivity, and energy expenditure, processes that can be influenced by adipokines in the brain and in peripheral tissues.

Keyword(s): adipokines, adipose, lactation, systems biology
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2018-02-15
2025-04-23
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Literature Cited

  1. Hajer GR, van Haeften TW, Visseren FLJ. 1.  2008. Adipose tissue dysfunction in obesity, diabetes and vascular diseases. Eur. Heart J. 29:2959–71 [Google Scholar]
  2. Satori C, Lazzeroni P, Merli S, Patianna VD, Viaroli F. 2.  et al. 2016. From placenta to polycystic ovary syndrome: the role of adipokines. Mediat. Inflamm. 2016:4981916 [Google Scholar]
  3. Roh SG, Suzuki Y, Goth T, Tatsumi R, Katoh K. 3.  2016. Invited review—physiological role of adipokines, hepatokines, and myokines in ruminants. Asian Austr. J. Anim. Sci. 29:1–15 [Google Scholar]
  4. Bauman DE, Currie WB. 4.  1980. Partitioning of nutrients during pregnancy and lactation: a review of mechanisms involving homeostasis and homeorhesis. J. Dairy Sci. 63:1514–29 [Google Scholar]
  5. Pond CM. 5.  1984. Physiological and ecological importance of energy storage in the evolution of lactation: evidence for a common pattern of anatomical organization of adipose tissue in mammals. Symp. Zool. Soc. Lond. 51:1 [Google Scholar]
  6. Kuhn NJ. 6.  1969. Progesterone withdrawal as the lactogenic trigger in the rat. J. Endocrinol. 44:39–54 [Google Scholar]
  7. Bauman DE, Elliot M. 7.  1980. Partitioning of nutrients during pregnancy and lactation: a review of mechanisms involving homeostasis and homeorhesis. J. Dairy Sci. 63:1514–29 [Google Scholar]
  8. Shields SL, Woelders H, Boer M, Stötzel C, Röeblitz S. 8.  et al. 2013. Integrating nutritional, genetic and reproductive management in early lactation dairy cattle. J. Anim. Sci. 90:1846–54 [Google Scholar]
  9. Palmquist DL. 9.  1976. A kinetic concept of lipid transport in ruminants: a review. J. Dairy Sci. 59:355–63 [Google Scholar]
  10. Pond CM, Mattacks CA. 10.  1989. Biochemical correlates of the structural allometry and site-specific properties of mammalian adipose tissue. Comp. Biochem. Physiol. A 92:455–63 [Google Scholar]
  11. Kuhn NJ, Lowenstein JM. 11.  1967. Lactogenesis in the rat: changes in metabolic parameters at parturition. Biochem. J. 105:955–1002 [Google Scholar]
  12. Edmonson AJ, Lean IJ, Weaver LD, Farver T, Webster G. 12.  1992. A body condition scoring chart for Holstein dairy cows. J. Dairy Sci 72:68–78 [Google Scholar]
  13. Morrow DA. 13.  1976. Fat cow syndrome. J. Dairy Sci. 59:1625–29 [Google Scholar]
  14. Freeman AE. 14.  1975. Genetic variation in nutrition of dairy cattle. The Effect of Genetic Variance on Nutritional Requirements of Animals: Proceedings of a Symposium19–46 Washington, DC: Natl. Acad. Press [Google Scholar]
  15. Baldwin RL, Smith NE. 15.  1971. Intermediary aspects and tissue interactions of ruminant fat metabolism. J. Dairy Sci. 54:583–95 [Google Scholar]
  16. Baldwin RL, Yang YT, Crist K, Grichting G. 16.  1976. Theoretical model of ruminant adipose tissue metabolism in relation to the whole animal. Fed. Proc. 35:2314–18 [Google Scholar]
  17. Yang YT, Baldwin RL. 17.  1973. Lipolysis in isolated cow adipose cells. J. Dairy Sci. 56:366–74 [Google Scholar]
  18. Yang YT, Baldwin RL. 18.  1973. Preparation and metabolism of isolated cells from bovine adipose tissue. J. Dairy Sci. 56:350–65 [Google Scholar]
  19. Shirley JE, Emery RS, Convey EM, Oxender WD. 19.  1973. Enzymic changes in bovine adipose and mammary tissue, serum and mammary tissue hormonal changes with initiation of lactation. J. Dairy Sci. 56:569–74 [Google Scholar]
  20. Sidhu KS, Emery RS. 20.  1972. Regulation of blood fatty acids and glycerol in lactating cows. J. Dairy Sci. 55:926–30 [Google Scholar]
  21. Metz SHM, Mulder L, Van den Bergh SG. 21.  1977. Regulation of lipolysis in bovine adipose tissue by the degree of saturation of plasma albumin with fatty acids. Biochim. Biophys. Acta 306:42–50 [Google Scholar]
  22. Metz SHM, Van den Bergh SG. 22.  1977. Regulation of fat mobilization in adipose tissue of dairy cows in the period around parturition. Neth. J. Agric. Sci. 25:198–211 [Google Scholar]
  23. Vernon RG. 23.  1980. Lipid metabolism in the adipose tissue of ruminant animals. Prog. Lipid Res. 19:23–106 [Google Scholar]
  24. Vernon RG, Finley B. 24.  1985. Regulation of lipolysis during pregnancy and lactation in sheep. Biochem. J. 230:651–56 [Google Scholar]
  25. Vernon RG, Finley B. 25.  1986. Lipolysis in rat adipocytes during recovery from lactation: response to noradrenaline and adenosine. Biochem. J. 234:229–31 [Google Scholar]
  26. Vernon RG, Finley B, Taylor E. 26.  1983. Adenosine and the control of lipolysis in rat adipocytes during pregnancy and lactation. Biochem. J. 216:121–28 [Google Scholar]
  27. Vernon RG, Clegg RA, Flint DI. 27.  1986. Adipose tissue metabolism in sheep: response to season and its modulation by reproductive state. Horm. Metab. Res. 18:308–12 [Google Scholar]
  28. Vernon RG, Finley B, Watt PW. 28.  1991. Adenosine and the control of adrenergic regulation of adipose tissue lipolysis during lactation. J. Dairy Sci. 74:695–705 [Google Scholar]
  29. Vernon RG, Taylor B. 29.  1986. Enzymes of adenosine metabolism of sheep adipose tissue: changes in activity with season, pregnancy and lactation. Horm. Metab. Res. 18:369 [Google Scholar]
  30. Vernon RG, Faulkner A, Finley B, Pollack A, Taylor B. 30.  1987. Enzymes of glucose and fatty acid metabolism of liver, kidney, skeletal muscle, adipose tissue and mammary gland of lactating and non-lactating sheep. J. Anim. Sci. 64:1395 [Google Scholar]
  31. Vernon RG, Finley B, Flint DL. 31.  1987. Role of growth hormone in the adaptations of lipolysis in rat adipocytes during recovery from lactation. Biochem. J. 242:931 [Google Scholar]
  32. Jaster EH, Wegner TN. 32.  1980. Beta-adrenergic receptor involvement in lipolysis of dairy cattle subcutaneous adipose tissue during dry and lactating state. J. Dairy Sci. 64:1655–63 [Google Scholar]
  33. Baldwin RL, Smith NE, Taylor J, Sharp M. 33.  1980. Manipulating metabolic parameters to improve growth rate and milk secretion. J. Anim. Sci. 51:1416–28 [Google Scholar]
  34. McNamara JP, Hillers JK. 34.  1986. Adaptations in lipid metabolism of bovine adipose tissue in lactogenesis and lactation. J. Lipid Res. 27:150–57 [Google Scholar]
  35. McNamara JP, Hillers JK. 35.  1986. Regulation of bovine adipose tissue metabolism during lactation. 2. Lipolysis response to milk production and energy in take. J. Dairy Sci. 69:3042–50 [Google Scholar]
  36. McNamara JP, McFarland DC, Bai S. 36.  1987. Regulation of bovine adipose tissue metabolism during lactation. 3. Adaptations in hormone sensitive and lipoprotein lipases. J. Dairy Sci. 70:1377–84 [Google Scholar]
  37. McNamara JP, Hillers JK. 37.  1989. Regulation of bovine adipose tissue metabolism during lactation. 5. Relationships of lipid synthesis and lipolysis with energy intake and utilization. J. Dairy Sci. 72:407–18 [Google Scholar]
  38. Smith DI, McNamara JP. 38.  1989. Lipolytic response of bovine adipose tissue to alpha and beta adrenergic agents 30 days pre- and 120 days postpartum. Gen. Pharmacol. 20:369–74 [Google Scholar]
  39. Smith TR, McNamara JP. 39.  1990. Regulation of bovine adipose tissue metabolism during lactation. 6. Cellularity and hormone-sensitive lipase activity as affected by genetic merit and energy intake. J. Daily Sci. 73:772–83 [Google Scholar]
  40. McNamara JP, Becker-Khaleel B, Parmley K. 40.  1992. Quantitative relationships between cyclic adenosine-3′,5′-monophosphate and lipolysis in adipose tissue during the peripartum period. J. Dairy Sci. 75:1901 [Google Scholar]
  41. McNamara JP. 41.  1988. Regulation of bovine adipose tissue metabolism during lactation. 4. Dose–responsiveness of epinephrine as altered by stage of lactation. J. Dairy Sci. 71:643–49 [Google Scholar]
  42. Probli DM, Blum JW. 42.  1988. Nonesterified fatty acids and glucose in lactating dairy cows: diurnal variations and changes in responsiveness during fasting to epinephrine and effects of beta-adrenergic blockade. J. Dairy Sci. 71:1170–77 [Google Scholar]
  43. Smith TR, McNamara JP. 43.  1990. Regulation of bovine adipose tissue metabolism during lactation 6. Cellularity and hormone sensitive lipase activity as affected by genetic merit and energy intake. J. Dairy Sci. 73:772–82 [Google Scholar]
  44. Kalkhoff RK, Kissebab AH, Kim HL. 44.  1978. Carbohydrate and lipid metabolism during normal pregnancy: relationship to gestational hormone action. Semin. Perinatol. 2:291–307 [Google Scholar]
  45. Chilliard Y, Sauvant P, Morando-Fehr, Dunshea C, FR, Bell AW, Trigg TE. 45.  1990. Body composition changes in goats during early lactation estimated using a two-pool model of tritiated water kinetics. Br. J. Nutr. 64:121–31 [Google Scholar]
  46. Robelin J, Chilliard Y, Agabriel J. 46.  1989. Estimation of body lipids and proteins of Holstein Charolaise and Limousine cows by dilution technique and adipose cell size. Proc. 11th Symp. Energy Met. Farm. Anim. Bur. Assoc. Anim. Prod. Publ. 43:370 [Google Scholar]
  47. McNamara JP, Dehoff MH, Bazer FW, Collier RJ. 47.  1985. Adipose tissue fatty acid metabolism changes during pregnancy in swine. J. Anim. Sci. 61:410–15 [Google Scholar]
  48. Sumner JM, McNamara JP. 48.  2007. Expression of lipolytic genes in the adipose tissue of pregnant and lactating Holstein dairy cattle. J. Dairy Sci. 90:5237–46 [Google Scholar]
  49. McNamara JP. 49.  2012. Ruminant Nutrition Symposium: a systems approach to integrating genetics, nutrition, and metabolic efficiency in dairy cattle. J. Anim. Sci. 90:1846–54 [Google Scholar]
  50. Sumner-Thompson JM, Vierck JL, McNamara JP. 50.  2011. Differential expression of genes in adipose tissue of first lactation dairy cattle. J. Dairy Sci. 94:361–69 [Google Scholar]
  51. Rocco SM, McNamara JP. 51.  2013. Regulation of bovine adipose tissue metabolism during lactation. 7. Metabolism and gene expression as a function of genetic merit and dietary energy intake. J. Dairy Sci. 96:3108–119 [Google Scholar]
  52. Koltes DA, Spurlock DM. 52.  2011. Coordination of lipid droplet associated proteins during the transition period of Holstein dairy cows. J. Dairy Sci. 94:1839–48 [Google Scholar]
  53. Elkins DA, Spurlock DM. 53.  2009. Phosphorylation of perilipin is associated with indicators of lipolysis in Holstein cows. Horm. Metab. Res. 41:736–40 [Google Scholar]
  54. Bionaz M, Loor JJ. 54.  2012. Ruminant metabolic systems biology: reconstruction and integration of transcriptome dynamics underlying functional responses of tissues to nutrition and physiological state. Gene Regul. Syst. Bio. 6:109–25 [Google Scholar]
  55. Drackley JK, Wallace RL, Graugnard D, Vasquez J, Richards BF, Loor JJ. 55.  2014. Visceral adipose tissue mass in nonlactating dairy cows fed diets differing in energy density. J. Dairy Sci. 97:63420–30 [Google Scholar]
  56. Hosseini A, Tariq MR, Trindade da Rosa F, Kesser J, Iqbal Z. 56.  et al. 2015. Insulin sensitivity in adipose and skeletal muscle tissue of dairy cows in response to dietary energy level and 2,4-thiazolidinedione (TZD). PLOS ONE 10:11e0142633 [Google Scholar]
  57. Vailati-Riboni M, Farina G, Batistel F, Heiser A, Mitchell MD. 57.  et al. 2017. Far-off and close-up dry matter intake modulate indicators of immunometabolic adaptations to lactation in subcutaneous adipose tissue of pasture-based transition dairy cows. J. Dairy Sci. 100:32334–50 [Google Scholar]
  58. Ji P, Drackley JK, Khan MJ, Loor JJ. 58.  2014. Overfeeding energy upregulates peroxisome proliferator-activated receptor (PPAR)γ-controlled adipogenic and lipolytic gene networks but does not affect proinflammatory markers in visceral and subcutaneous adipose depots of Holstein cows. J. Dairy Sci. 97:63431–40 [Google Scholar]
  59. Ji P, Drackley JK, Khan MJ, Loor JJ. 59.  2014. Inflammation- and lipid metabolism-related gene network expression in visceral and subcutaneous adipose depots of Holstein cows. J. Dairy Sci. 97:63441–48 [Google Scholar]
  60. Mukesh M, Bionaz M, Graugnard DE, Drackley JK, Loor JJ. 60.  2010. Adipose tissue depots of Holstein cows are immune responsive: inflammatory gene expression in vitro. Domest. Anim. Endocrinol. 38:3168–78 [Google Scholar]
  61. Khan M, Hosseini A, Burrell S, Rocco SM, McNamara JP, Loor J. 61.  2013. Change in subcutaneous adipose tissue metabolism and gene network expression during the transition period in dairy cows, including differences due to sire genetic merit. J. Dairy Sci. 96:2171–82 [Google Scholar]
  62. Wang M, Zhou Z, Khan MJ, Gao J, Loor JJ. 62.  2015. Clock circadian regulator (CLOCK) gene network expression patterns in bovine adipose, liver, and mammary gland at 3 time points during the transition from pregnancy into lactation. J. Dairy Sci. 98:74601–12 [Google Scholar]
  63. Colitti M, Loor JJ, Stefanon B. 63.  2015. Expression of NGF, BDNF and their receptors in subcutaneous adipose tissue of lactating cows. Res. Vet. Sci. 102:196–99 [Google Scholar]
  64. Loor JJ, Bionaz M, Drackley JK. 64.  2014. Systems physiology in dairy cattle: nutritional genomics and beyond. Annu. Rev. Anim. Biosci. 1:365–92 [Google Scholar]
  65. Otto TC, Lane MD. 65.  2005. Adipose development: from stem cell to adipocyte. Crit. Rev. Biochem. Mol. Biol. 40:229–42 [Google Scholar]
  66. Ohtani Y, Yonezawa T, Song SH, Takahashi T, Ardiyanti A. 66.  et al. 2011. Gene expression and hormonal regulation of adiponectin and its receptors in bovine mammary gland and mammary epithelial cells. Anim. Sci. J. 82:99–106 [Google Scholar]
  67. Singh SP, Häussler S, Heinz JFL, Akter AH, Saremi B. 67.  et al. 2014. Lactation driven dynamics of adiponectin supply from different fat depots to circulation in cows. Dom. Anim. Endocrinol. 47:35–46 [Google Scholar]
  68. Ohtani Y, Takahashi T, Sato K, Ardiyanti A, Song SH. 68.  et al. 2012. Changes in circulating adiponectin and metabolic hormone concentrations during periparturient and lactation periods in Holstein dairy cows. Anim. Sci. J. 83:788–95 [Google Scholar]
  69. Kabara E, Sordillo LM, Holcombe S, Contreras GA. 69.  2013. Adiponectin links adipose tissue function and monocyte inflammatory responses during bovine metabolic stress. Comp. Immunol. Microbiol. Infect. Dis. 37:49–58 [Google Scholar]
  70. Saremi B, Winand S, Friedrichs P, Kinoshita A, Rehage J. 70.  et al. 2014. Longitudinal profiling of the tissue-specific expression of genes related with insulin sensitivity in dairy cows during lactation focusing on different fat depots. PLOS ONE 9:e86211 [Google Scholar]
  71. Weber M, Locher L, Huber K, Rehage J, Tienken R. 71.  et al. 2016. Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation. Part 2: the SIRT-PPARGC1A axis and its relationship with the adiponectin system. J. Dairy Sci. 99:1560–70 [Google Scholar]
  72. Asai-Sato M, Okamoto M, Endo M, Yoshida H, Mutase M. 72.  et al. 2006. Hypoadiponectinemia in lean lactating women: Prolactin inhibits adiponectin secretion from human adipocytes. Endocrin. J. 53:555–62 [Google Scholar]
  73. Nilsson L, Binart N, Bohlooly-Y M, Brammert M, Egecioglu E. 73.  et al. 2005. Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue. Biochem. Biophys. Res. Comm. 331:1120–26 [Google Scholar]
  74. Lemor A, Hosseini A, Sauerwein H, Mielenz M. 74.  2009. Transition period-related changes in the abundance of the mRNAs of adiponectin and its receptors, of visfatin, and of fatty acid binding receptors in adipose tissue of high-yielding dairy cows. Dom. Anim. Endocrinol. 37:37–44 [Google Scholar]
  75. Lemor A, Mielenz M, Altmann M, von Borell E, Sauerwein H. 75.  2010. mRNA abundance of adiponectin and its receptors, leptin and visfatin and of G-protein coupled receptor 41 in five different fat depots from sheep. Anim. Physiol. Anim. Nutr. 94:e96–e101 [Google Scholar]
  76. Lord E, Ledoux S, Murphy BD, Beaudry D, Palin MF. 76.  2005. Expression of adiponectin and its receptors in swine. J. Anim. Sci. 83:565–78 [Google Scholar]
  77. Chappaz E, Albornoz MS, Campos D, Che L, Palin MF. 77.  et al. 2008. Adiponectin enhances in vitro development of swine embryos. Domest. Anim. Endocrinol. 35:198–207 [Google Scholar]
  78. Yamauchi T, Iwabu M, Okada-Iwabu M, Kadowaki T. 78.  2014. Adiponectin receptors: a review of their structure, function and how they work. Best Pract. Res. Clin. Endocrinol. Metab. 28:15–23 [Google Scholar]
  79. Ledoux S, Campos DB, Lopes FL, Dobias-Goff M, Palin MF, Murphy BD. 79.  2006. Adiponectin induces periovulatory changes in ovarian follicular cells. Endocrinology 147:5178–86 [Google Scholar]
  80. Block SS, Butler WR, Ehrhardt RA, Bell AW, Van Amburgh ME, Boisclair YR. 80.  2001. Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance. J. Endocrinol. 171:339–48 [Google Scholar]
  81. Holness MJ, Munns MJ, Sugden MC. 81.  1999. Current concepts concerning the role of leptin in reproductive function. Mol. Cell. Endocrinol. 157:11–20 [Google Scholar]
  82. Wang Y, Hou Q, Cai G, Hu Z, Shi K. 82.  et al. 2017. Effects of dietary energy density in the dry period on the production performance and metabolism of dairy cows. Adv. Biosci. Biotechnol. 8:104–26 [Google Scholar]
  83. Feuermann Y, Mabjeesh SJ, Niv-Spector L, Levin D, Shamay A. 83.  2006. Prolactin affects leptin action in the bovine mammary gland via mammary fat pad. J. Endocrinol. 191:407–13 [Google Scholar]
  84. Mountzih K, Qiu J, Ewart-Toland A, Chehab F. 84.  1998. Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistance state. Endocrinology 139:5259–62 [Google Scholar]
  85. Bonnet M, Gourdou I, Leroux C, Chilliard Y, Djiane J. 85.  2002. Leptin expression in the ovine mammary gland: putative sequential involvement of adipose, epithelial, and myoepithelial cells during pregnancy and lactation. J. Anim. Sci. 80:723–28 [Google Scholar]
  86. Tygesen MP, Nielsen MO, Norgaard P, Ranvig H, Harrison AP, Tauson AH. 86.  2008. Late gestational nutrient restriction: effects on ewe's metabolic and homeorhetic adaptation, consequences for lamb birth weight and lactation performance. Arch. Anim. Nutr. 62:44–59 [Google Scholar]
  87. Bertolucci C, Caola G, Foa G, Piccione G. 87.  2005. Daily rhythms of serum leptin in ewes: effects of feeding, pregnancy and lactation. Chronobiol. Int. 22:817–27 [Google Scholar]
  88. DeRensis F, Gherpelli M, Superchi P, Kirkwood RN. 88.  2005. Relationships between backfat depth and plasma leptin and sow reproductive performance after weaning. Anim. Reprod. Sci. 90:95–100 [Google Scholar]
  89. Wolinski J, Slupecka M, Romanowicz K. 89.  2014. Leptin and ghrelin levels in colostrum, milk and blood plasma of sows and pig neonates during the first week of lactation. Anim. Sci. J. 85:143–49 [Google Scholar]
  90. Estienne MJ, Harper AF, Barb CR, Azain MJ. 90.  2000. Concentrations of leptin in serum and milk collected from lactating sows differing in body condition. Domest. Anim. Endocrinol. 19:275–80 [Google Scholar]
  91. Summer A, Saleri R, Malacarne M, Bussolati S, Beretti V. 91.  et al. 2008. Leptin in sow: influence on the resumption of cycle activity after weaning and on piglet gain. Livest. Sci. 124:107–11 [Google Scholar]
  92. Weber M, Locher L, Huber K, Kenez A, Rehage J. 92.  et al. 2016. Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation. Part 1: the adipokines apelin and resistin and their relationship to receptors linked with lipolysis. J. Dairy Sci. 99:1549–59 [Google Scholar]
  93. Reverchon M, Rame C, Cognie J, Briant E, Elis S. 93.  et al. 2014. Resistin in dairy cows: plasma concentrations during early lactation, expression and potential role in adipose tissue. PLOS ONE 9:e93198 [Google Scholar]
  94. Wellen KE, Hotamisgli GS. 94.  2005. Inflammation, stress, and diabetes. J. Clin. Investig. 115:1111–19 [Google Scholar]
  95. Kushibiki S. 95.  2011. Tumor necrosis factor-α-induced inflammatory responses in cattle. Anim. Sci. J. 82:504–11 [Google Scholar]
  96. Mecitoglu Z, Senturk S, Akgul G, Udum D, Uzabaci E. 96.  et al. 2016. Changes in circulating adiponectin and tumour necrosis factor-α and their relationship with insulin resistance in periparturient dairy cows. J. Vet. Res. 60:163–67 [Google Scholar]
  97. Farney JM, Mamedova LK, Coetzee JF, KuKanich B, Sordillo LM. 97.  et al. 2013. Anti-inflammatory salicylate treatment alters the metabolic adaptation to lactation in dairy cattle. Am. J. Physiol. Regul. Integr. Comp. Physiol. 305:R110–17 [Google Scholar]
  98. O'Boyle N, Corl CM, Gandy JC, Sordillo LM. 98.  2006. Relationship of body condition score and oxidant stress to tumor necrosis factor expression in dairy cattle. Vet. Immunol. Immunopathol. 113:297–304 [Google Scholar]
  99. Sadri H, Bruckmaier RM, Rahmani HR, Ghorbani GR, Morel I, van Dorland HA. 99.  2010. Gene expression of tumour necrosis factor and insulin-signalling related factors in subcutaneous adipose tissue during the dry period and in early lactation on dairy cows. J. Anim. Physiol. Anim. Nutr. 94:e194–e202 [Google Scholar]
  100. Papadopoulos GA, Maes DGD, Van Weyenberg S, van Kempen TATG, Buyse J, Janssens GPJ. 100.  2009. Peripartal feeding strategy with different n-6: n-3 ratios in sows: effects on sow's performance, inflammatory and periparturient metabolic parameters. Br. J. Nutr. 101:348–57 [Google Scholar]
  101. Baldwin RL. 101.  1995. Modeling Ruminant Digestion and Metabolism New York: Chapman & Hall [Google Scholar]
  102. McNamara JP. 102.  2015. Systems biology of regulatory mechanisms of nutrient metabolism in lactation. J. Anim. Sci. 93:5575–85 [Google Scholar]
  103. McNamara JP, Pettigrew JE. 103.  2002. Protein and energy intake in lactating sows. 1: effects on milk production and body composition. J. Anim. Sci. 80:2442–51 [Google Scholar]
  104. McNamara JP, Pettigrew JE. 104.  2002. Protein and energy intake in lactating sows. 2. Challenging parameters of a model of metabolism. J. Anim. Sci. 80:2452–60 [Google Scholar]
  105. McNamara JP, Shields SL. 105.  2013. Reproduction during lactation of dairy cattle: integrating nutritional aspects of reproductive control in a systems research approach. Anim. Front. 3:76–83 [Google Scholar]
  106. McNamara JP, Huber K, Kenez A. 106.  2016. A dynamic, mechanistic model of metabolism in adipose tissue of lactating dairy cattle. J. Dairy Sci. 99:5649–61 [Google Scholar]
  107. McNamara JP, Hanigan MD, White RR. 107.  2016. Invited review: experimental design, data reporting and sharing in support of animal systems modeling research. J. Dairy Sci. 99:9355–71 [Google Scholar]
/content/journals/10.1146/annurev-animal-030117-014720
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Metabolic and Endocrine Role of Adipose Tissue During Lactation
Annual Review of Animal Biosciences 6, 177 (2018); https://doi.org/10.1146/annurev-animal-030117-014720
/content/journals/10.1146/annurev-animal-030117-014720
/content/journals/10.1146/annurev-animal-030117-014720
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