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Abstract

Micro- or minimally invasive glaucoma surgeries (MIGS) have been the latest addition to the glaucoma surgical treatment paradigm. This term refers not to a single surgery, but rather to a group of distinct procedures and devices that aim to decrease intraocular pressure. Broadly, MIGS can be categorized into surgeries that increase the trabecular outflow [Trabectome, iStent (first and second generations), Hydrus microstent, Kahook Dual Blade and gonioscopy-assisted transluminal trabeculotomy], surgeries that increase suprachoroidal outflow (Cypass microstent and iStent Supra), and conjunctival bleb-forming procedures (Xen gel stent and InnFocus microshunt). Compared to traditional glaucoma surgeries, such as trabeculectomy and glaucoma drainage device implantation (Ahmed, Baerveldt, and Molteno valves), MIGS are touted to have less severe complications and shorter surgical time. MIGS represent an evolving field, and the efficacy and complications of each procedure should be considered independently, giving more importance to high-quality and longer-term studies.

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2020-09-15
2024-04-24
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Literature Cited

  1. Ahmed IIK 2015. MIGS and the FDA: What's in a name. Ophthalmology 122:91737–39
    [Google Scholar]
  2. Ahmed IIK, Durr G, Varma D 2019. Air XEN gel stent implantation Video, Am. Acad. Ophthalmol San Francisco, CA: https://www.aao.org/master-class-video/air-xen-gel-stent-implantation
  3. Ahmed IIK, Fea A, Au L, Ang RE, Harasymowycz P et al. 20120. A prospective randomized trial comparing Hydrus and iStent microinvasive glaucoma surgery implants for standalone treatment of open-angle glaucoma: the COMPARE study. Ophthalmology 127:52–61
    [Google Scholar]
  4. Ahmed IIK, Katz LJ, Chang DF, Donnenfeld ED, Solomon KD et al. 2014. Prospective evaluation of microinvasive glaucoma surgery with trabecular microbypass stents and prostaglandin in open-angle glaucoma. J. Cataract Refract. Surg. 40:81295–300
    [Google Scholar]
  5. Ahmed SF, Bhatt A, Schmutz M, Mosaed S 2018. Trabectome outcomes across the spectrum of glaucoma disease severity. Graefes Arch. Clin. Exp. Ophthalmol. 256:91703–10
    [Google Scholar]
  6. Ahn R, Woodbridge A, Abraham A, Saba S, Korenstein D et al. 2017. Financial ties of principal investigators and randomized controlled trial outcomes: cross sectional study. BMJ 356:i6770
    [Google Scholar]
  7. Akil H, Chopra V, Huang A, Loewen N, Noguchi J, Francis BA 2016. Clinical results of ab interno trabeculotomy using the Trabectome in patients with pigmentary glaucoma compared to primary open angle glaucoma. Clin. Experiment. Ophthalmol. 44:7563–69
    [Google Scholar]
  8. Akil H, Chopra V, Huang AS, Swamy R, Francis BA 2017. Short-term clinical results of ab interno trabeculotomy using the Trabectome with or without cataract surgery for open-angle glaucoma patients of high intraocular pressure. J. Ophthalmol. 2017:8248710
    [Google Scholar]
  9. Aktas Z, Bektas C, Hasanreisoglu M 2019a. Panscleritis as an unusual complication of gonioscopy-assisted transluminal trabeculotomy. J. Glaucoma 28:2e21–23
    [Google Scholar]
  10. Aktas Z, Ucgul AY, Bektas C, Sahin Karamert S 2019b. Surgical outcomes of prolene gonioscopy assisted transluminal trabeculotomy in patients with moderate to advanced open-angle glaucoma. J. Glaucoma 28:884–88
    [Google Scholar]
  11. Alasbali T, Smith M, Geffen N, Trope GE, Flanagan JG et al. 2009. Discrepancy between results and abstract conclusions in industry- versus nonindustry-funded studies comparing topical prostaglandins. Am. J. Ophthalmol. 147:133–38.e2
    [Google Scholar]
  12. Ali ZC, Khoo DI, Stringa F, Shankar V 2019. Migration of XEN45 implant: findings, mechanism, and management. J. Curr. Glaucoma Pract. 13:279–81
    [Google Scholar]
  13. Anderson TS, Good CB, Gellad WF 2015. Prevalence and compensation of academic leaders, professors, and trustees on publicly traded US healthcare company boards of directors: cross sectional study. BMJ 351:h4826
    [Google Scholar]
  14. Arad T, Hoffmann EM, Prokosch-Willing V, Pfeiffer N, Grehn F 2019. XEN-augmented Baerveldt implantation for refractory childhood glaucoma: a retrospective case series. J. Glaucoma 28:1015–18
    [Google Scholar]
  15. Arnould L, Theillac V, Moran S, Gatinel D, Grise-Dulac A 2019. Recurrent exposure of XEN gel stent implant and conjunctival erosion. J. Glaucoma 28:3e37–40
    [Google Scholar]
  16. Arora S, Maeda M, Francis B, Maeda M, Sit AJ et al. 2018. Efficacy and safety of ab interno trabeculectomy in juvenile open-angle glaucoma. Can. J. Ophthalmol. 53:5482–86
    [Google Scholar]
  17. Arrieta EA, Aly M, Parrish R, Dubovy S, Pinchuk L et al. 2011. Clinicopathologic correlations of poly-(styrene-b-isobutylene-b-styrene) glaucoma drainage devices of different internal diameters in rabbits. Ophthalmic Surg. Lasers Imaging 42:4338–45
    [Google Scholar]
  18. Arriola-Villalobos P, Martínez-de-la-Casa JM, Díaz-Valle D, Fernández-Pérez C, García-Sánchez J, García-Feijoó J 2012. Combined iStent trabecular micro-bypass stent implantation and phacoemulsification for coexistent open-angle glaucoma and cataract: a long-term study. Br. J. Ophthalmol. 96:5645–49
    [Google Scholar]
  19. Arriola-Villalobos P, Martínez-de-la-Casa JM, Díaz-Valle D, García-Vidal SE, Fernández-Pérez C et al. 2013. Mid-term evaluation of the new Glaukos iStent with phacoemulsification in coexistent open-angle glaucoma or ocular hypertension and cataract. Br. J. Ophthalmol. 97:101250–55
    [Google Scholar]
  20. Arriola-Villalobos P, Martínez-de-la-Casa JM, Díaz-Valle D, Morales-Fernandez L, Fernández-Pérez C, García-Feijoó J 2016. Glaukos iStent inject® trabecular micro-bypass implantation associated with cataract surgery in patients with coexisting cataract and open-angle glaucoma or ocular hypertension: a long-term study. J. Ophthalmol. 2016:1056573
    [Google Scholar]
  21. Atalay K, Nacaroglu SA, Kirgiz A 2018. Complication of micro-bypass stenting: the anterior chamber displacement of a Xen implant. Arq. Bras. Oftalmol. 81:6514–16
    [Google Scholar]
  22. Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y et al. 2004. Grading quality of evidence and strength of recommendations. BMJ 328:74541490
    [Google Scholar]
  23. Baerveldt G, Chuck R. 2005. Minimally invasive glaucoma surgical instrument and method US Patent 6:979,328B2
  24. Bahler CK, Hann CR, Fjield T, Haffner D, Heitzmann H, Fautsch MP 2012. Second-generation trabecular meshwork bypass stent (iStent inject) increases outflow facility in cultured human anterior segments. Am. J. Ophthalmol. 153:61206–13
    [Google Scholar]
  25. Baker CB, Johnsrud MT, Crismon ML, Rosenheck RA, Woods SW 2003. Quantitative analysis of sponsorship bias in economic studies of antidepressants. Br. J. Psychiatry 183:6498–506
    [Google Scholar]
  26. Barnett SJ, Katz A. 2015. Patients as partners in innovation. Semin. Pediatr. Surg. 24:3141–44
    [Google Scholar]
  27. Batlle JF, Fantes F, Riss I, Pinchuk L, Alburquerque R et al. 2016. Three-year follow-up of a novel aqueous humor microshunt. J. Glaucoma 25:2e58–65
    [Google Scholar]
  28. Baykara M, Poroy C, Erseven C 2019. Surgical outcomes of combined gonioscopy-assisted transluminal trabeculotomy and cataract surgery. Ind. J. Ophthalmol. 67:4505–8
    [Google Scholar]
  29. Beckers H, Kujovic‐Aleksov S, Webers C, Riss I, Batlle J, Parel J 2017. One-year results of a three-site study of the InnFocus microshunt. Acta Ophthalmol 95:28–29
    [Google Scholar]
  30. Berdahl JP, Khatana AK, Katz LJ, Herndon L, Layton AJ et al. 2017. Cost-comparison of two trabecular micro-bypass stents versus selective laser trabeculoplasty or medications only for intraocular pressure control for patients with open-angle glaucoma. J. Med. Econ. 20:7760–66
    [Google Scholar]
  31. Bloom P, Au L. 2018. “Minimally invasive glaucoma surgery (MIGS) is a poor substitute for trabeculectomy”—the great debate. Ophthalmol. Ther. 7:2203–10
    [Google Scholar]
  32. Boese EA, Shah M. 2019. Gonioscopy-assisted transluminal trabeculotomy (GATT) is an effective procedure for steroid-induced glaucoma. J. Glaucoma 28:9803–7
    [Google Scholar]
  33. Boyd EA, Bero LA. 2007. Defining financial conflicts and managing research relationships: an analysis of university conflict of interest committee decisions. Sci. Eng. Ethics 13:4415–35
    [Google Scholar]
  34. Buchacra O, Duch S, Milla E, Stirbu O 2011. One-year analysis of the iStent trabecular microbypass in secondary glaucoma. Clin. Ophthalmol. 5:321–26
    [Google Scholar]
  35. Bussel II, Kaplowitz K, Schuman JS, Loewen NA, Group Trabectome Study 2015a. Outcomes of ab interno trabeculectomy with the trabectome by degree of angle opening. Br. J. Ophthalmol. 99:7914–19
    [Google Scholar]
  36. Bussel II, Kaplowitz K, Schuman JS, Loewen NA 2015b. Outcomes of ab interno trabeculectomy with the trabectome after failed trabeculectomy. Br. J. Ophthalmol. 99:2258–62
    [Google Scholar]
  37. Bustros Y, Chaudhary A, Salinas L, Mansouri K 2020. Cutting the subconjunctival fragment of the XEN gel implant during needling procedure. Eur. J. Ophthalmol. 30:NP11–15
    [Google Scholar]
  38. CADTH 2019. Optimal use of minimally invasive glaucoma surgery: a health technology assessment Rep., CADTH Ottawa, Can:.
  39. Caprioli J, Kim JH, Friedman DS, Kiang T, Moster MR et al. 2015. Special commentary: supporting innovation for safe and effective minimally invasive glaucoma surgery: summary of a joint meeting of the American Glaucoma Society and the Food and Drug Administration, Washington, DC, February 26, 2014. Ophthalmology 122:91795–801
    [Google Scholar]
  40. Cent. Devices Radiol. Health 2019. Hydrus® Microstent—P170034 Rep., Cent. Devices Radiol. Health, U.S. Food Drug Admin Silver Spring, MD:
  41. Cent. Medicare Medicaid Serv 2013. Medicare, Medicaid, Children's Health Insurance Programs; transparency reports and reporting of physician ownership or investment interests. Federal Register Feb. 8. https://www.federalregister.gov/documents/2013/02/08/2013-02572/medicare-medicaid-childrens-health-insurance-programs-transparency-reports-and-reporting-of
    [Google Scholar]
  42. Chatzara A, Chronopoulou I, Theodossiadis G, Theodossiadis P, Chatziralli I 2019. XEN implant for glaucoma treatment: a review of the literature. Semin. Ophthalmol. 34:293–97
    [Google Scholar]
  43. Chen KH, Kim WI. 2018. Implantation of a CyPass supraciliary stent combined with targeted iStent trabecular microbypass stents in a phakic patient with primary open-angle glaucoma. J. Glaucoma 27:2e37–39
    [Google Scholar]
  44. Cigarroa FG, Masters BS, Sharphorn D 2018. Institutional conflicts of interest and public trust. JAMA 320:222305–6
    [Google Scholar]
  45. Conlon R, Saheb H, Ahmed IIK 2017. Glaucoma treatment trends: a review. Can. J. Ophthalmol. 52:1114–24
    [Google Scholar]
  46. Cosgrove L, Krimsky S, Wheeler EE, Peters SM, Brodt M, Shaughnessy AF 2017. Conflict of interest policies and industry relationships of guideline development group members: a cross-sectional study of clinical practice guidelines for depression. Account. Res. 24:299–115
    [Google Scholar]
  47. Craven ER, Katz LJ, Wells JM, Giamporcaro JE 2012. Cataract surgery with trabecular micro-bypass stent implantation in patients with mild-to-moderate open-angle glaucoma and cataract: two-year follow-up. J. Cataract Refract. Surg. 38:81339–45
    [Google Scholar]
  48. Damji KF, Behki R, Wang L 2003. Canadian perspectives in glaucoma management: setting target intraocular pressure range. Can. J. Ophthalmol. 38:3189–97
    [Google Scholar]
  49. Dang Y, Kaplowitz K, Parikh HA, Roy P, Loewen RT et al. 2016. Steroid-induced glaucoma treated with trabecular ablation in a matched comparison with primary open-angle glaucoma. Clin. Experiment. Ophthalmol. 44:9783–88
    [Google Scholar]
  50. Dervenis N, Mikropoulou AM, Dervenis P, Lewis A 2017. Dislocation of a previously successful XEN glaucoma implant into the anterior chamber: a case report. BMC Ophthalmol 17:1148
    [Google Scholar]
  51. Djulbegovic B, Guyatt GH. 2017. Progress in evidence-based medicine: a quarter century on. Lancet 390:10092415–23
    [Google Scholar]
  52. Djulbegovic B, Guyatt GH, Ashcroft RE 2009. Epistemologic inquiries in evidence-based medicine. Cancer Control 16:2158–68
    [Google Scholar]
  53. Donnenfeld ED, Solomon KD, Voskanyan L, Chang DF, Samuelson TW et al. 2015. A prospective 3-year follow-up trial of implantation of two trabecular microbypass stents in open-angle glaucoma. Clin. Ophthalmol. 9:2057–65
    [Google Scholar]
  54. Dorairaj SK, Kahook MY, Williamson BK, Seibold LK, ElMallah MK, Singh IP 2018a. A multicenter retrospective comparison of goniotomy versus trabecular bypass device implantation in glaucoma patients undergoing cataract extraction. Clin. Ophthalmol. 12:791–97
    [Google Scholar]
  55. Dorairaj SK, Seibold LK, Radcliffe NM, Aref AA, Jimenez-Román J et al. 2018b. 12-month outcomes of goniotomy performed using the Kahook Dual Blade combined with cataract surgery in eyes with medically treated glaucoma. Adv. Ther. 35:91460–69
    [Google Scholar]
  56. Dorairaj SK, Tam MD. 2019. Kahook Dual Blade excisional goniotomy and goniosynechialysis combined with phacoemulsification for angle-closure glaucoma: 6-month results. J. Glaucoma 28:7643–46
    [Google Scholar]
  57. Dunn AG, Coiera E, Mandl KD, Bourgeois FT 2016. Conflict of interest disclosure in biomedical research: a review of current practices, biases, and the role of public registries in improving transparency. Res. Integr. Peer Rev. 1:1
    [Google Scholar]
  58. ElMallah MK, Seibold LK, Kahook MY, Williamson BK, Singh IP et al. 2019. 12-month retrospective comparison of Kahook Dual Blade excisional goniotomy with iStent trabecular bypass device implantation in glaucomatous eyes at the time of cataract surgery. Adv. Ther. 36:92515–27
    [Google Scholar]
  59. Eloy JA, Kilic S, Yoo NG, Mcleod T, Svider PF et al. 2017. Is industry funding associated with greater scholarly impact among academic neurosurgeons?. World Neurosurg 103:517–25
    [Google Scholar]
  60. Eur. Glaucoma Soc 2017. European Glaucoma Society terminology and guidelines for glaucoma, 4th edition—chapter 3: treatment principles and options. Supported by the EGS Foundation. Part 1: foreword; introduction; glossary; chapter 3 treatment principles and options. Br. J. Ophthalmol. 101:6130–95
    [Google Scholar]
  61. Fea AM. 2010. Phacoemulsification versus phacoemulsification with micro-bypass stent implantation in primary open-angle glaucoma: randomized double-masked clinical trial. J. Cataract Refract. Surg. 36:3407–12
    [Google Scholar]
  62. Fea AM, Ahmed IIK, Lavia C, Mittica P, Consolandi G et al. 2017a. Hydrus microstent compared to selective laser trabeculoplasty in primary open angle glaucoma: one year results. Clin. Experiment. Ophthalmol. 45:2120–27
    [Google Scholar]
  63. Fea AM, Belda JI, Rękas M, Jünemann A, Chang L et al. 2014. Prospective unmasked randomized evaluation of the iStent inject® versus two ocular hypotensive agents in patients with primary open-angle glaucoma. Clin. Ophthalmol. 8:875–82
    [Google Scholar]
  64. Fea AM, Consolandi G, Zola M, Pignata G, Cannizzo P et al. 2015. Micro-bypass implantation for primary open-angle glaucoma combined with phacoemulsification: 4-year follow-up. J. Ophthalmol. 2015:795357
    [Google Scholar]
  65. Fea AM, Spinetta R, Cannizzo PML, Consolandi G, Lavia C et al. 2017b. Evaluation of bleb morphology and reduction in IOP and glaucoma medication following implantation of a novel gel stent. J. Ophthalmol. 2017:9364910
    [Google Scholar]
  66. Fechtner RD, Voskanyan L, Vold SD, Tetz M, Auffarth G et al. 2019. Five-year, prospective, randomized, multi-surgeon trial of two trabecular bypass stents versus prostaglandin for newly diagnosed open-angle glaucoma. Ophthalmol. Glaucoma 2:3156–66
    [Google Scholar]
  67. Fernández-Barrientos Y, García-Feijoó J, Martínez-de-la-Casa JM, Pablo LE, Fernández-Pérez C, García Sánchez J 2010. Fluorophotometric study of the effect of the glaukos trabecular microbypass stent on aqueous humor dynamics. Investig. Ophthalmol. Vis. Sci. 51:73327–32
    [Google Scholar]
  68. Fontelo P, Liu F. 2018. A review of recent publication trends from top publishing countries. Syst. Rev. 7:147
    [Google Scholar]
  69. Francis BA, Minckler D, Dustin L, Kawji S, Yeh J et al. 2008. Combined cataract extraction and trabeculotomy by the internal approach for coexisting cataract and open-angle glaucoma: initial results. J. Cataract Refract. Surg. 34:71096–103
    [Google Scholar]
  70. Francis BA, Winarko J. 2012. Ab interno Schlemm's canal surgery: Trabectome and I-Stent. Dev. Ophthalmol. 50:125–36
    [Google Scholar]
  71. Friedman LS, Richter ED. 2004. Relationship between conflicts of interest and research results. J. Gen. Intern. Med. 19:151–56
    [Google Scholar]
  72. Galal A, Bilgic A, Eltanamly R, Osman A 2017. XEN glaucoma implant with mitomycin C 1-year follow-up: result and complications. J. Ophthalmol. 2017:5457246
    [Google Scholar]
  73. García-Feijoo J, Höh H, Uzunov R, Dickerson JE 2018. Supraciliary microstent in refractory open-angle glaucoma: two-year outcomes from the DUETTE trial. J. Ocul. Pharmacol. Ther. 34:7538–42
    [Google Scholar]
  74. García-Feijoo J, Rau M, Grisanti S, Grisanti S, Höh H et al. 2015. Supraciliary micro-stent implantation for open-angle glaucoma failing topical therapy: 1-year results of a multicenter study. Am. J. Ophthalmol. 159:61075–81.e1
    [Google Scholar]
  75. Gedde SJ, Feuer WJ, Shi W, Lim KS, Barton K et al. 2018. Treatment outcomes in the primary tube versus trabeculectomy study after 1 year of follow-up. Ophthalmology 125:5650–63
    [Google Scholar]
  76. Gillmann K, Bravetti GE, Mermoud A, Mansouri K 2019a. Anterior chamber XEN gel stent movements: the impact on corneal endothelial cell density. J. Glaucoma 28:6e93–95
    [Google Scholar]
  77. Gillmann K, Bravetti GE, Mermoud A, Rao HL, Mansouri K 2019b. XEN gel stent in pseudoexfoliative glaucoma: 2-year results of a prospective evaluation. J. Glaucoma 28:8676–84
    [Google Scholar]
  78. Gillmann K, Mansouri K, Bravetti GE, Mermoud A 2018. Chronic intraocular inflammation as a risk factor for XEN gel stent occlusion: a case of microscopic examination of a fibrin-obstructed XEN stent. J. Glaucoma 27:8739–41
    [Google Scholar]
  79. Glujovsky D, Sueldo CE, Borghi C, Nicotra P, Andreucci S, Ciapponi A 2016. Misleading reporting and interpretation of results in major infertility journals. Fertil. Steril. 105:51301–6
    [Google Scholar]
  80. Godlee F. 2015. Conflict of interest: forward not backward. BMJ 350:h3176
    [Google Scholar]
  81. Gold MR, Siegel JE, Russell LB, Russell LB, Weinstein MC 1996. Cost-Effectiveness in Health and Medicine Oxford, UK: Oxford Univ. Press
  82. Gonnermann J, Bertelmann E, Pahlitzsch M, Maier-Wenzel A-KB, Torun N, Klamann MKJ 2017. Contralateral eye comparison study in MICS & MIGS: Trabectome® versus iStent inject®. Graefes Arch. Clin. Exp. Ophthalmol. 255:2359–65
    [Google Scholar]
  83. Green W, Lind JT, Sheybani A 2018. Review of the Xen gel stent and InnFocus microshunt. Curr. Opin. Ophthalmol. 29:2162–70
    [Google Scholar]
  84. Greenwood MD, Seibold LK, Radcliffe NM, Dorairaj SK, Aref AA et al. 2017. Goniotomy with a single-use dual blade: short-term results. J. Cataract Refract. Surg. 43:91197–201
    [Google Scholar]
  85. Grisanti S, Grisanti S, Garcia-Feijoo J, Dick HB, Munoz-Negrete FJ et al. 2018. Supraciliary microstent implantation for open-angle glaucoma: multicentre 3-year outcomes. BMJ Open Ophthalmol 3:1e000183
    [Google Scholar]
  86. Grover DS, Fellman RL. 2016. Gonioscopy-assisted transluminal trabeculotomy (GATT): thermal suture modification with a dye-stained rounded tip. J. Glaucoma 25:6501–4
    [Google Scholar]
  87. Grover DS, Flynn WJ, Bashford KP, Lewis RA, Duh Y-J et al. 2017a. Performance and safety of a new ab interno gelatin stent in refractory glaucoma at 12 months. Am. J. Ophthalmol. 183:25–36
    [Google Scholar]
  88. Grover DS, Godfrey DG, Smith O, Feuer WJ, Montes de Oca I, Fellman RL 2014. Gonioscopy-assisted transluminal trabeculotomy, ab interno trabeculotomy: technique report and preliminary results. Ophthalmology 121:4855–61
    [Google Scholar]
  89. Grover DS, Godfrey DG, Smith O, Shi W, Feuer WJ, Fellman RL 2017b. Outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in eyes with prior incisional glaucoma surgery. J. Glaucoma 26:141–45
    [Google Scholar]
  90. Grover DS, Smith O, Fellman RL, Godfrey DG, Butler MR et al. 2015. Gonioscopy assisted transluminal trabeculotomy: an ab interno circumferential trabeculotomy for the treatment of primary congenital glaucoma and juvenile open angle glaucoma. Br. J. Ophthalmol. 99:81092–96
    [Google Scholar]
  91. Grover DS, Smith O, Fellman RL, Godfrey DG, Gupta A et al. 2018. Gonioscopy-assisted transluminal trabeculotomy: an ab interno circumferential trabeculotomy: 24 months follow-up. J. Glaucoma 27:5393–401
    [Google Scholar]
  92. Guyatt GH, Sackett DL, Sinclair JC, Hayward R, Cook DJ, Cook RJ 1995. Users’ guides to the medical literature. IX. A method for grading health care recommendations. Evidence-Based Medicine Working Group. JAMA 274:221800–4
    [Google Scholar]
  93. Hashemian SJ, Miraftabi A, Jafari ME, Hemami MR 2017. Combined cataract extraction and trabeculotomy by the internal approach for coexisting cataract and open-angle glaucoma. J. Curr. Ophthalmol. 29:117–22
    [Google Scholar]
  94. Hengerer FH, Auffarth GU, Riffel C, Conrad-Hengerer I 2018. Prospective, non-randomized, 36-month study of second-generation trabecular micro-bypass stents with phacoemulsification in eyes with various types of glaucoma. Ophthalmol. Ther. 7:2405–15
    [Google Scholar]
  95. Hengerer FH, Auffarth GU, Riffel C, Conrad-Hengerer I 2019. Second-generation trabecular micro-bypass stents as standalone treatment for glaucoma: a 36-month prospective study. Adv. Ther. 36:71606–17
    [Google Scholar]
  96. Hernstadt DJ, Cheng J, Htoon HM, Sangtam T, Thomas A, Sng CCA 2019. Case series of combined iStent implantation and phacoemulsification in eyes with primary angle closure disease: one-year outcomes. Adv. Ther. 36:4976–86
    [Google Scholar]
  97. Hoeh H, Ahmed IIK, Grisanti S, Grisanti S, Grabner G et al. 2013. Early postoperative safety and surgical outcomes after implantation of a suprachoroidal micro-stent for the treatment of open-angle glaucoma concomitant with cataract surgery. J. Cataract Refract. Surg. 39:3431–37
    [Google Scholar]
  98. Hoeh H, Vold SD, Ahmed IK, Anton A, Rau M et al. 2016. Initial clinical experience with the CyPass micro-stent: safety and surgical outcomes of a novel supraciliary microstent. J. Glaucoma 25:1106–12
    [Google Scholar]
  99. Höh H, Grisanti S, Grisanti S, Rau M, Ianchulev S 2014. Two-year clinical experience with the CyPass micro-stent: safety and surgical outcomes of a novel supraciliary micro-stent. Klin. Monbl. Augenheilkd. 231:4377–81
    [Google Scholar]
  100. Hohberger B, Welge-Lüßen U-C, Lämmer R 2018. MIGS: therapeutic success of combined Xen gel stent implantation with cataract surgery. Graefes Arch. Clin. Exp. Ophthalmol. 256:3621–25
    [Google Scholar]
  101. Hopen ML, Patel S, Gallardo MJ 2018. CyPass supraciliary stent in eye with chronic angle closure and postvitrectomy with silicone oil. J. Glaucoma 27:10e151–53
    [Google Scholar]
  102. Huang W, Wang W, Zhan J, Zhou M, Chen S, Zhang X 2013. Scientific publications in ophthalmic journals from China and other top-ranking countries: a 12-year review of the literature. BMC Ophthalmol 13:25
    [Google Scholar]
  103. Iordanous Y, Kent JS, Hutnik CML, Malvankar-Mehta MS 2014. Projected cost comparison of Trabectome, iStent, and endoscopic cyclophotocoagulation versus glaucoma medication in the Ontario Health Insurance Plan. J. Glaucoma 23:2e112–18
    [Google Scholar]
  104. Jea SY, Francis BA, Vakili G, Filippopoulos T, Rhee DJ 2012. Ab interno trabeculectomy versus trabeculectomy for open-angle glaucoma. Ophthalmology 119:136–42
    [Google Scholar]
  105. Jit M. 2018. MCDA from a health economics perspective: opportunities and pitfalls of extending economic evaluation to incorporate broader outcomes. Cost Eff. Resour. Alloc. 16:Suppl 145
    [Google Scholar]
  106. Johnson J, Rogers W. 2012. Innovative surgery: the ethical challenges. J. Med. Ethics 38:19–12
    [Google Scholar]
  107. Jones J, Koch DD, Vold S, McCabe C, Rhee D et al. 2019. Results from the United States cohort of the HORIZON trial of a Schlemm canal microstent to reduce intraocular pressure in primary open-angle glaucoma. J. Cataract Refract. Surg. 45:91305–15
    [Google Scholar]
  108. Jordan JF, Wecker T, van Oterendorp C, Anton A, Reinhard T et al. 2013. Trabectome surgery for primary and secondary open angle glaucomas. Graefes Arch. Clin. Exp. Ophthalmol. 251:122753–60
    [Google Scholar]
  109. Junemann A. 2013. Twelve-month outcomes following ab interno implantaton of suprachoroidal stent and postoperative administration of Travoprost to treat open angle glaucoma Paper presented at ESCRS Annual Meeting Amsterdam:
  110. Kalina AG, Kalina PH, Brown MM 2019. XEN® gel stent in medically refractory open-angle glaucoma: results and observations after one year of use in the United States. Ophthalmol. Ther. 8:3435–46
    [Google Scholar]
  111. Kaplowitz K, Loewen NA. 2015. Trabectome-mediated ab interno trabeculectomy for secondary glaucoma or as a secondary procedure. Advanced Glaucoma Surgery AA Aref, R Varma 15–29 Berlin: Springer
    [Google Scholar]
  112. Kaplowitz K, Schuman JS, Loewen NA 2014. Techniques and outcomes of minimally invasive trabecular ablation and bypass surgery. Br. J. Ophthalmol. 98:5579–85
    [Google Scholar]
  113. Kaptchuk TJ. 2001. The double-blind, randomized, placebo-controlled trial: gold standard or golden calf. J. Clin. Epidemiol. 54:6541–49
    [Google Scholar]
  114. Karri B, Gupta C, Mathews D 2018. Endophthalmitis following XEN stent exposure. J. Glaucoma 27:10931–33
    [Google Scholar]
  115. Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL et al. 2002. The Ocular Hypertension Treatment Study: A randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch. Ophthalmol. 120:6701–13; discussion 829–30
    [Google Scholar]
  116. Katz LJ, Erb C, Carceller GA, Fea AM, Voskanyan L et al. 2015. Prospective, randomized study of one, two, or three trabecular bypass stents in open-angle glaucoma subjects on topical hypotensive medication. Clin. Ophthalmol. 9:2313–20
    [Google Scholar]
  117. Katz LJ, Erb C, Carceller GA, Fea AM, Voskanyan L et al. 2018. Long-term titrated IOP control with one, two, or three trabecular micro-bypass stents in open-angle glaucoma subjects on topical hypotensive medication: 42-month outcomes. Clin. Ophthalmol. 12:255–62
    [Google Scholar]
  118. Khouri AS, Wong SH. 2017. Ab interno trabeculectomy with a dual blade: surgical technique for childhood glaucoma. J. Glaucoma 26:8749–51
    [Google Scholar]
  119. Kim KT, Eo MY, Nguyen TTH, Kim SM 2019. General review of titanium toxicity. Int. J. Implant Dent. 5:10
    [Google Scholar]
  120. Kinoshita-Nakano E, Nakanishi H, Ohashi-Ikeda H, Morooka S, Akagi T 2018. Comparative outcomes of trabeculotomy ab externo versus trabecular ablation ab interno for open angle glaucoma. Jpn. J. Ophthalmol. 62:2201–8
    [Google Scholar]
  121. Lapira M, Cronbach N, Shaikh A 2018. Extrusion and breakage of XEN gel stent resulting in endophthalmitis. J. Glaucoma 27:10934–35
    [Google Scholar]
  122. Lass JH, Benetz BA, He J, Hamilton C, Von Tress M et al. 2019. Corneal endothelial cell loss and morphometric changes 5 years after phacoemulsification with or without CyPass micro-stent. Am. J. Ophthalmol. 208:211–18
    [Google Scholar]
  123. Lavia C, Dallorto L, Maule M, Ceccarelli M, Fea AM 2017. Minimally-invasive glaucoma surgeries (MIGS) for open angle glaucoma: a systematic review and meta-analysis. PLOS ONE 12:8e0183142
    [Google Scholar]
  124. Lee JWY, Yick DWF, Tsang S, Yuen CYF, Lai JSM 2016. Efficacy and safety of Trabectome surgery in Chinese open-angle glaucoma. Medicine 95:15e3212
    [Google Scholar]
  125. Lee RMH, Bouremel Y, Eames I, Brocchini S, Khaw PT 2019. The implications of an ab interno versus ab externo surgical approach on outflow resistance of a subconjunctival drainage device for intraocular pressure control. Trans. Vis. Sci. Tech. 8:358
    [Google Scholar]
  126. Lenzhofer M, Kersten-Gomez I, Sheybani A, Gulamhusein H, Strohmaier C et al. 2019a. Four-year results of a minimally invasive transscleral glaucoma gel stent implantation in a prospective multi-centre study. Clin. Experiment. Ophthalmol. 47:5581–87
    [Google Scholar]
  127. Lenzhofer M, Strohmaier C, Hohensinn M, Hitzl W, Sperl P et al. 2019b. Longitudinal bleb morphology in anterior segment OCT after minimally invasive transscleral ab interno glaucoma gel microstent implantation. Acta Ophthalmol 97:2e231–37
    [Google Scholar]
  128. Lenzhofer M, Strohmaier C, Hohensinn M, Hitzl W, Steiner V et al. 2019c. Change in visual acuity 12 and 24 months after transscleral ab interno glaucoma gel stent implantation with adjunctive Mitomycin C. Graefes Arch. Clin. Exp. Ophthalmol. 257:2707–15
    [Google Scholar]
  129. Liesegang TJ, Bartley GB. 2014a. Toward transparency of financial disclosure. Ophthalmology 121:112077–78
    [Google Scholar]
  130. Liesegang TJ, Bartley GB. 2014b. Footnotes, acknowledgments, and authorship: toward greater responsibility, accountability, and transparency. Ophthalmology 121:122297–98
    [Google Scholar]
  131. Lin MM, Morgan WH, Kolomeyer NN, Moster SJ, Zheng CX et al. 2019. XEN gel stent to treat ICE syndrome: 4 cases. J. Glaucoma 28:1090–94
    [Google Scholar]
  132. Loewenstein G, Sah S, Cain DM 2012. The unintended consequences of conflict of interest disclosure. JAMA 307:7669–70
    [Google Scholar]
  133. Lundh A, Lexchin J, Mintzes B, Schroll JB, Bero L 2017. Industry sponsorship and research outcome. Cochrane Database Syst. Rev. 2:MR000033
    [Google Scholar]
  134. Maeda M, Watanabe M, Ichikawa K 2013. Evaluation of trabectome in open-angle glaucoma. J. Glaucoma 22:3205–8
    [Google Scholar]
  135. Malvankar-Mehta MS, Chen YN, Iordanous Y, Wang WW, Costella J, Hutnik CML 2015. iStent as a solo procedure for glaucoma patients: a systematic review and meta-analysis. PLOS ONE 10:5e0128146
    [Google Scholar]
  136. Mansberger SL, Gordon MO, Jampel H, Bhorade A, Brandt JD et al. 2012. Reduction in intraocular pressure after cataract extraction: the Ocular Hypertension Treatment Study. Ophthalmology 119:91826–31
    [Google Scholar]
  137. Mansouri K, Gillmann K, Rao HL, Guidotti J, Mermoud A 2018. Prospective evaluation of XEN gel implant in eyes with pseudoexfoliative glaucoma. J. Glaucoma 27:10869–73
    [Google Scholar]
  138. Markel H. 2013. Patents, profits, and the American people—the Bayh-Dole Act of 1980. New Engl. J. Med. 369:9794–96
    [Google Scholar]
  139. Mathew DJ, McKay BR, Basilious A, Belkin A, Trope GE, Buys YM 2019. Adherence to World Glaucoma Association guidelines for surgical trials in the era of microinvasive glaucoma surgeries. Ophthalmol. Glaucoma 2:278–85
    [Google Scholar]
  140. McKinney RE. 2016. Institutional conflict of interest and the translational pathway. JAMA Ophthalmol 134:5483–84
    [Google Scholar]
  141. McKinney RE. 2018. Institutional Conflict of Interest in Research Policy—Duke University Policy, Duke Univ Durham, NC:
  142. Midha N, Rao HL, Mermoud A, Mansouri K 2019. Identifying the predictors of needling after XEN gel implant. Eye 33:3353–57
    [Google Scholar]
  143. Miller VJ, Young CEC, SooHoo JR, Seibold LK, Kahook MY et al. 2019. Efficacy of goniotomy with Kahook Dual Blade in patients with uveitis-associated ocular hypertension. J. Glaucoma 28:8744–48
    [Google Scholar]
  144. Minckler DS, Baerveldt G, Alfaro MR, Francis BA 2005. Clinical results with the Trabectome for treatment of open-angle glaucoma. Ophthalmology 112:6962–67
    [Google Scholar]
  145. Minckler DS, Baerveldt G, Ramirez MA, Mosaed S, Wilson R et al. 2006. Clinical results with the Trabectome, a novel surgical device for treatment of open-angle glaucoma. Trans. Am. Ophthalmol. Soc. 104:40–50
    [Google Scholar]
  146. Minckler DS, Mosaed S, Dustin L, Ms BF 2008. Trabectome (trabeculectomy-internal approach): additional experience and extended follow-up. Trans. Am. Ophthalmol. Soc. 106:149–59; discussion 159–60
    [Google Scholar]
  147. Mizoguchi T, Nishigaki S, Sato T, Wakiyama H, Ogino N 2015. Clinical results of Trabectome surgery for open-angle glaucoma. Clin. Ophthalmol. 9:1889–94
    [Google Scholar]
  148. Mosaed S, Chak G, Haider A, Lin KY, Minckler DS 2015. Results of trabectome surgery following failed glaucoma tube shunt implantation: cohort study. Medicine 94:30e1045
    [Google Scholar]
  149. Muth CC. 2017. Conflict of interest in medicine. JAMA 317:171812
    [Google Scholar]
  150. Myers J, Katz J. 2013. Open angle glaucoma treated with a suprachoroidal stent and topical Travoprost Paper presented at the 23rd Annual American Glaucoma Society Meeting San Francisco, CA:
  151. Myers JS, Masood I, Hornbeak DM, Belda JI, Auffarth G et al. 2018. Prospective evaluation of two iStent® trabecular stents, one iStent Supra® suprachoroidal stent, and postoperative prostaglandin in refractory glaucoma: 4-year outcomes. Adv. Ther. 35:3395–407
    [Google Scholar]
  152. Nazarali S, Arora A, Ford B, Schlenker M, Ahmed IK et al. 2019. Cadaver corneoscleral model for angle surgery training. J. Cataract Refract. Surg. 45:176–79
    [Google Scholar]
  153. Nazarali SA, Damji KF. 2018. Ab interno trabeculectomy with Trabectome: outcomes in African American versus Caucasian patients. Can. J. Ophthalmol. 53:4361–64
    [Google Scholar]
  154. Neuhann TH. 2015. Trabecular micro-bypass stent implantation during small-incision cataract surgery for open-angle glaucoma or ocular hypertension: long-term results. J. Cataract Refract. Surg. 41:122664–71
    [Google Scholar]
  155. Ngan K, Fraser E, Buller S, Buller A 2018. A cost minimisation analysis comparing iStent accompanying cataract surgery and selective laser trabeculoplasty versus topical glaucoma medications in a public healthcare setting in New Zealand. Graefes Arch. Clin. Exp. Ophthalmol. 256:112181–89
    [Google Scholar]
  156. Ohmann C, Banzi R, Canham S, Battaglia S, Matei M et al. 2017. Sharing and reuse of individual participant data from clinical trials: principles and recommendations. BMJ Open 7:12e018647
    [Google Scholar]
  157. Olate-Pérez Á, Pérez-Torregrosa VT, Gargallo-Benedicto A, Escudero-Igualada R, Cerdà-Ibáñez M et al. 2018. Management of conjunctival perforation and late Seidel after XEN® surgery. Arch. Soc. Esp. Oftalmol. 93:293–96
    [Google Scholar]
  158. Olate-Pérez Á, Pérez-Torregrosa VT, Gargallo-Benedicto A, Neira-Ibáñez P, Cerdà-Ibáñez M et al. 2017. Prospective study of filtering blebs after XEN45 surgery. Arch. Soc. Esp. Oftalmol. 92:8366–71
    [Google Scholar]
  159. Ordóñez JE, Ordóñez A, Osorio UM 2019. Cost-effectiveness analysis of iStent trabecular micro-bypass stent for patients with open-angle glaucoma in Colombia. Curr. Med. Res. Opin. 35:2329–40
    [Google Scholar]
  160. Patel I, de Klerk TA, Au L 2013. Manchester iStent study: early results from a prospective UK case series. Clin. Experiment. Ophthalmol. 41:7648–52
    [Google Scholar]
  161. Patel V, Ahmed I, Podbielski D, Falvey H, Murray J, Goeree R 2019. Cost-effectiveness analysis of standalone trabecular micro-bypass stents in patients with mild-to-moderate open-angle glaucoma in Canada. J. Med. Econ. 22:4390–401
    [Google Scholar]
  162. Pfeiffer N, Garcia-Feijoo J, Martinez-de-la-Casa JM, Larrosa JM, Fea A et al. 2015. A randomized trial of a Schlemm's canal microstent with phacoemulsification for reducing intraocular pressure in open-angle glaucoma. Ophthalmology 122:71283–93
    [Google Scholar]
  163. Pinchuk L, Riss I, Batlle JF, Kato YP, Martin JB et al. 2016. The use of poly(styrene-block-isobutylene-block-styrene) as a microshunt to treat glaucoma. Regen. Biomater. 3:2137–42
    [Google Scholar]
  164. Pisano ED, Golden RN, Schweitzer L 2014. Conflict of interest policies for academic health system leaders who work with outside corporations. JAMA 311:111111–12
    [Google Scholar]
  165. Prokosch-Willing V, Vossmerbaeumer U, Hoffmann E, Pfeiffer N 2017. Suprachoroidal bleeding after XEN gel implantation. J. Glaucoma 26:12e261–63
    [Google Scholar]
  166. Rahmatnejad K, Pruzan NL, Amanullah S, Shaukat BA, Resende AF et al. 2017. Surgical outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with open-angle glaucoma. J. Glaucoma 26:121137–43
    [Google Scholar]
  167. Reiss G, Clifford B, Vold S, He J, Hamilton C et al. 2019. Safety and effectiveness of CyPass supraciliary micro-stent in primary open-angle glaucoma: five-year results from the COMPASS XT study. Am. J. Ophthalmol. 208:219–25
    [Google Scholar]
  168. Reitsamer H, Sng C, Vera V, Lenzhofer M, Barton K et al. 2019. Two-year results of a multicenter study of the ab interno gelatin implant in medically uncontrolled primary open-angle glaucoma. Graefes Arch. Clin. Exp. Ophthalmol. 257:5983–96
    [Google Scholar]
  169. Resende AF, Patel NS, Waisbourd M, Katz LJ 2016. iStent® trabecular microbypass stent: an update. J. Ophthalmol. 2016:2731856
    [Google Scholar]
  170. Riss I, Batlle J, Pinchuk L, Kato YP, Weber BA, Parel J-M 2015. One-year results on the safety and efficacy of the InnFocus microshunt™ depending on placement and concentration of mitomycin C. J. Fr. Ophtalmol. 38:9855–60
    [Google Scholar]
  171. Sackett DL, Rosenberg WM, Gray JA, Haynes RB, Richardson WS 1996. Evidence based medicine: what it is and what it isn't. BMJ 312:702371–72
    [Google Scholar]
  172. Salinas L, Chaudhary A, Berdahl JP, Lazcano-Gomez GS, Williamson BK et al. 2018a. Goniotomy using the Kahook Dual Blade in severe and refractory glaucoma: 6-month outcomes. J. Glaucoma 27:10849–55
    [Google Scholar]
  173. Salinas L, Chaudhary A, Guidotti J, Mermoud A, Mansouri K 2018b. Revision of a leaking bleb with XEN gel stent replacement. J. Glaucoma 27:1e11–13
    [Google Scholar]
  174. Samuelson TW, Chang DF, Marquis R, Flowers B, Lim KS et al. 2019a. A Schlemm canal microstent for intraocular pressure reduction in primary open-angle glaucoma and cataract: the HORIZON study. Ophthalmology 126:129–37
    [Google Scholar]
  175. Samuelson TW, Katz LJ, Wells JM, Duh Y-J, Giamporcaro JE, iStent Study Group US 2011. Randomized evaluation of the trabecular micro-bypass stent with phacoemulsification in patients with glaucoma and cataract. Ophthalmology 118:3459–67
    [Google Scholar]
  176. Samuelson TW, Sarkisian SR, Lubeck DM, Stiles MC, Duh Y-J et al. 2019b. Prospective, randomized, controlled pivotal trial of an ab interno implanted trabecular micro-bypass in primary open-angle glaucoma and cataract: two-year results. Ophthalmology 126:6811–21
    [Google Scholar]
  177. Schaefer JL, Aubert Bonn N, Craenen G 2017. Declaring conflict of interest—current state of affairs in the ophthalmic literature. Account. Res. 24:7375–83
    [Google Scholar]
  178. Schlenker MB, Gulamhusein H, Conrad-Hengerer I, Somers A, Lenzhofer M et al. 2017. Efficacy, safety, and risk factors for failure of standalone ab interno gelatin microstent implantation versus standalone trabeculectomy. Ophthalmology 124:111579–88
    [Google Scholar]
  179. Seibold LK, Soohoo JR, Ammar DA, Kahook MY 2013. Preclinical investigation of ab interno trabeculectomy using a novel dual-blade device. Am. J. Ophthalmol. 155:3524–29.e2
    [Google Scholar]
  180. Shaarawy TM, Sherwood MB, Grehn F 2009. Guidelines on Design and Reporting of Glaucoma Surgical Trials Amsterdam: Kugler Publ.
  181. Shiba D, Hosoda S, Yaguchi S, Ozeki N, Yuki K, Tsubota K 2017. Safety and efficacy of two trabecular micro-bypass stents as the sole procedure in Japanese patients with medically uncontrolled primary open-angle glaucoma: a pilot case series. J. Ophthalmol. 2017:9605461
    [Google Scholar]
  182. Shrime MG, Alkire BC, Grimes C, Chao TE, Poenaru D, Verguet S 2017. Cost-effectiveness in global surgery: pearls, pitfalls, and a checklist. World J. Surg. 41:61401–13
    [Google Scholar]
  183. Sii S, Triolo G, Barton K 2019. Case series of hypotony maculopathy after CyPass insertion treated with intra-luminal suture occlusion. Clin. Experiment. Ophthalmol. 47:5679–80
    [Google Scholar]
  184. Sims MT, Bowers AM, Fernan JM, Dormire KD, Herrington JM, Vassar M 2018. Trial registration and adherence to reporting guidelines in cardiovascular journals. Heart 104:9753–59
    [Google Scholar]
  185. Smilowitz NR, Ferguson JJ, Weisz G 2018. Controversies surrounding authorship of manuscripts by industry employees: academic and industry perspectives. EuroIntervention 13:161967–74
    [Google Scholar]
  186. Sng CC, Wang J, Hau S, Htoon HM, Barton K 2018. XEN-45 collagen implant for the treatment of uveitic glaucoma. Clin. Experiment. Ophthalmol. 46:4339–45
    [Google Scholar]
  187. SooHoo JR, Seibold LK, Radcliffe NM, Kahook MY 2014. Minimally invasive glaucoma surgery: current implants and future innovations. Can. J. Ophthalmol. 49:6528–33
    [Google Scholar]
  188. Spiegel D, García-Feijoó J, García-Sánchez J, Lamielle H 2008. Coexistent primary open-angle glaucoma and cataract: preliminary analysis of treatment by cataract surgery and the iStent trabecular micro-bypass stent. Adv. Ther. 25:5453–64
    [Google Scholar]
  189. Spiegel D, Wetzel W, Neuhann T, Stuermer J, Hoeh H et al. 2009. Coexistent primary open-angle glaucoma and cataract: interim analysis of a trabecular micro-bypass stent and concurrent cataract surgery. Eur. J. Ophthalmol. 19:3393–99
    [Google Scholar]
  190. Tan SZ, Au L. 2016. Manchester iStent study: 3-year results and cost analysis. Eye 30:101365–70
    [Google Scholar]
  191. Tassel SHV, Ertel MK, Muylaert SJ 2019. Metal intraocular particles following microinvasive glaucoma surgery with stents. Ophthalmol. Glaucoma 2:5363
    [Google Scholar]
  192. Taylor SC, Huecker JB, Gordon MO, Vollman DE, Apte RS 2016. Physician-industry interactions and anti-vascular endothelial growth factor use among US ophthalmologists. JAMA Ophthalmol 134:8897–903
    [Google Scholar]
  193. Thomas R, Mengersen K. 2013. Is the observed lowering of intraocular pressure due to treatment. Ind. J. Ophthalmol. 61:3119–21
    [Google Scholar]
  194. Ting JLM, Damji KF, Stiles MC 2012. Ab interno trabeculectomy: outcomes in exfoliation versus primary open-angle glaucoma. J. Cataract Refract. Surg. 38:2315–23
    [Google Scholar]
  195. Ting JLM, Rudnisky CJ, Damji KF 2018. Prospective randomized controlled trial of phaco-trabectome versus phaco-trabeculectomy in patients with open angle glaucoma. Can. J. Ophthalmol. 53:6588–94
    [Google Scholar]
  196. Tojo N, Abe S, Miyakoshi M, Hayashi A 2017. Comparison of intraocular pressure fluctuations before and after ab interno trabeculectomy in pseudoexfoliation glaucoma patients. Clin. Ophthalmol. 11:1667–75
    [Google Scholar]
  197. U.S. Food Drug Admin 2018. Alcon announces voluntary global market withdrawal of CyPass micro-stent for surgical glaucoma Rep., U.S. Food Drug Admin Silver Spring, MD:
  198. Vandewalle E, Zeyen T, Stalmans I 2009. The iStent trabecular micro-bypass stent: a case series. Bull. Soc. Belge. Ophtalmol. 311:23–29
    [Google Scholar]
  199. Vijaya L, Manish P, Ronnie G, Shantha B 2011. Management of complications in glaucoma surgery. Ind. J. Ophthalmol. 59:Suppl.S131–40
    [Google Scholar]
  200. Vold S, Ahmed IIK, Craven ER, Mattox C, Stamper R et al. 2016. Two-year COMPASS trial results: supraciliary microstenting with phacoemulsification in patients with open-angle glaucoma and cataracts. Ophthalmology 123:102103–12
    [Google Scholar]
  201. Voskanyan L, García-Feijoó J, Belda JI, Fea A, Jünemann A et al. 2014. Prospective, unmasked evaluation of the iStent® inject system for open-angle glaucoma: synergy trial. Adv. Ther. 31:2189–201
    [Google Scholar]
  202. Wellik SR, Dale EA. 2015. A review of the iStent® trabecular micro-bypass stent: safety and efficacy. Clin. Ophthalmol. 9:677–84
    [Google Scholar]
  203. Widder JR, Schmitz JW. 2019. Combining ab interno Kahook trabeculectomy with gonioscopy-assisted transluminal trabeculotomy reduces intraocular pressure. Mil. Med 184:934–36
    [Google Scholar]
  204. Yalinbas D, Aktas Z, Hepsen İ, Dilekmen N 2018. An unusual complication of combined gonioscopy-assisted transluminal trabeculotomy and phacoemulsification: vision loss due to intracapsular hematoma. Int. Ophthalmol. 38:52223–26
    [Google Scholar]
  205. Yildirim Y, Kar T, Duzgun E, Sagdic SK, Ayata A, Unal MH 2016. Evaluation of the long-term results of trabectome surgery. Int. Ophthalmol. 36:5719–26
    [Google Scholar]
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